4,6-二碘嘧啶-2-胺 | 861031-48-3

• 物质功能分类: 医药中间体 - 杂环化合物 - 嘧啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 4,6-二碘嘧啶-2-胺
• 英文名称: 2-amino-4,6-diiodopyrimidine
• 英文别名: 4,6-diiodopyrimidin-2-ylamine；4,6-Dijod-pyrimidin-2-ylamin；4,6-diiodopyrimidin-2-amine
• CAS: 861031-48-3
• 化学式: C₄H₃I₂N₃
• 分子量: 346.897
• InChiKey: KCXYZQGKUXCZLR-UHFFFAOYSA-N

物化性质

• 熔点：
  222-224 °C (decomp)
• 沸点：
  455.0±48.0 °C(Predicted)
• 密度：
  2.836±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

制备方法与用途

2-氨基-4,6-二碘嘧啶是一种很有用的研究化合物。

反应信息

• 作为反应物：
  描述：

  4,6-二碘嘧啶-2-胺 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 2-氨基-4-羟基-6-碘嘧啶
  参考文献：
  名称：

  Design and Synthesis of a DNA-Like Structure Composed of Alkynyl C-Nucleotide with 2-Aminopyrimidin-4-one as a Nucleobase

  摘要：

  A heterocyclic compound, 2-aminopyrimidin-4-one, was found to be a new candidate of a non-natural nucleobase that forms a novel base pair by self-dimerization. 2-Aminopyrimidin-4-one was connected to a deoxyribose through an acetylene linkage. The non-natural nucleoside was derivatized to its phosphoramidite that could be subjected to a conventional solid-phase DNA synthesis. The solid-phase auto-synthesis successfully afforded a non-natural DNA-like oligomer bearing 2-aminopyrimidin-4-one as a nucleobase. The synthetic oligomer exhibited reversible formation of a higher-order structure that would be a duplex like natural DNA. The present study means creation of a novel artificial DNA-like system with unordinary odd numbers of genetic alphabets.

  DOI：

  10.3987/com-18-s(t)53
• 作为产物：
  描述：

  2-氨基-4,6-二氯嘧啶 在 氢碘酸 、 potassium iodide 作用下， 以94%的产率得到4,6-二碘嘧啶-2-胺
  参考文献：
  名称：

  包含交替的2-氨基-嘧啶和亚苯基重复单元的新型可溶性硬质棒状共聚物：合成，表征，光学和电化学性质

  摘要：

  通过Sonogashira缩聚反应，在2-氨基-4,6-二碘乙嘧啶和1,4-二溴-2,5-二烷氧基苯之间制备了一种新型的2-氨基嘧啶的π共轭共聚物。通过FT-IR，1 H NMR和13 C NMR，荧光光谱，凝胶渗透色谱，热分析和元素分析来阐明共聚物的结构。衍生的聚合物可溶于常见的有机溶剂和三氟乙酸，并表现出良好的热稳定性。他们分别在固态紫外线照射下发出绿光和溶液相发出蓝光或绿光。这些新型聚合物的电化学行为描述浅显p掺杂和良好的电子传输性能。当用CH质子化这些聚合物显示红移3 SO 3 H酸在氯仿溶液或米甲酚溶液和红移峰，观察到从490纳米至652纳米。共聚物的XRD图谱表明，随着烷氧基链长度的增加，峰的强度增加。

  DOI：

  10.1016/j.polymer.2009.11.010

文献信息

• New soluble rigid rod copolymers comprising alternating 2-amino-pyrimidine and phenylene repeat units: Syntheses, characterization, optical and electrochemical properties
  作者：Xirali Mamtimin、Rukiya Matsidik、Ismayil Nurulla

  DOI：10.1016/j.polymer.2009.11.010

  日期：2010.1

  organic solvents and trifloroacetic acid and exhibited good thermal stability. They emitted green light under UV irradiation in solid state and blue or green light in solution phase, respectively. Electrochemical behavior of these new polymers depicted facile p-doping and good electron-transporting properties. These polymers displayed bathochromic shift when protonated with CH3SO3H acid in chloroform solutions

  通过Sonogashira缩聚反应，在2-氨基-4,6-二碘乙嘧啶和1,4-二溴-2,5-二烷氧基苯之间制备了一种新型的2-氨基嘧啶的π共轭共聚物。通过FT-IR，1 H NMR和13 C NMR，荧光光谱，凝胶渗透色谱，热分析和元素分析来阐明共聚物的结构。衍生的聚合物可溶于常见的有机溶剂和三氟乙酸，并表现出良好的热稳定性。他们分别在固态紫外线照射下发出绿光和溶液相发出蓝光或绿光。这些新型聚合物的电化学行为描述浅显p掺杂和良好的电子传输性能。当用CH质子化这些聚合物显示红移3 SO 3 H酸在氯仿溶液或米甲酚溶液和红移峰，观察到从490纳米至652纳米。共聚物的XRD图谱表明，随着烷氧基链长度的增加，峰的强度增加。
• 1H-Pyrrolo[2,3 b]pyridine derivatives
  申请人：Heinrich Timo

  公开号：US20130231519A1

  公开（公告）日：2013-09-05

  1H-Pyrrolo[2,3-b]pyridine compounds are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours.

  1H-Pyrrolo[2,3-b]pyridine化合物是细胞增殖/细胞活力的抑制剂，可用于治疗肿瘤。
• Efficient Synthesis of Pyrimidinecarbonitriles and Their Derivatives
  作者：Petra Doláková、Milena Masojídková、Antonín Holy

  DOI：10.3987/com-07-11014

  日期：——

  New approach to pyrimidinecarbonitriles was developed. Pyrimidine-4- and 6-carbonitriles were prepared by palladium-catalyzed cross-coupling reaction of iodopyrimidines with Zn(CN)2 in very good yields. The cyano group was converted into the corresponding acyl groups by the treatment with Grignard reagents and transformed to amido and imido function as well.
• DE738497
  申请人：——

  公开号：——

  公开（公告）日：——
• Design and Synthesis of a DNA-Like Structure Composed of Alkynyl C-Nucleotide with 2-Aminopyrimidin-4-one as a Nucleobase
  作者：Junya Chiba、Masahiko Inouye、Fumihiro Kurosaki

  DOI：10.3987/com-18-s(t)53

  日期：——

  A heterocyclic compound, 2-aminopyrimidin-4-one, was found to be a new candidate of a non-natural nucleobase that forms a novel base pair by self-dimerization. 2-Aminopyrimidin-4-one was connected to a deoxyribose through an acetylene linkage. The non-natural nucleoside was derivatized to its phosphoramidite that could be subjected to a conventional solid-phase DNA synthesis. The solid-phase auto-synthesis successfully afforded a non-natural DNA-like oligomer bearing 2-aminopyrimidin-4-one as a nucleobase. The synthetic oligomer exhibited reversible formation of a higher-order structure that would be a duplex like natural DNA. The present study means creation of a novel artificial DNA-like system with unordinary odd numbers of genetic alphabets.