1-{3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl}-4,4-diphenyl-4-silapiperidine | 839677-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-{3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl}-4,4-diphenyl-4-silapiperidine
• 英文别名: 1-[3-[2-(4-Fluorophenyl)-1,3-dioxolan-2-yl]propyl]-4,4-diphenyl-1,4-azasilinane；1-[3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl]-4,4-diphenyl-1,4-azasilinane
• CAS: 839677-32-6
• 化学式: C₂₈H₃₂FNO₂Si
• 分子量: 461.651
• InChiKey: BZETWSWDXGAXDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.38
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-{3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl}-4,4-diphenyl-4-silapiperidine 在 盐酸 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以88%的产率得到1-[4-oxo-4-(4-fluorophenyl)butyl]-4,4-diphenyl-4-silapiperidine
  参考文献：
  名称：

  4-Silapiperidine and 4-silapiperidinium derivatives: syntheses and structural characterization

  摘要：

  A series of novel 4-silapiperidine and 4-silapiperidinium derivatives, with two silicon-bound aryl groups and various N-organyl groups, have been synthesized and structurally characterized (solution H-1, C-13, F-19, and Si-29 NMR spectroscopy; eight crystal structure analyses). These synthetic and structural investigations provide the basis for the development of novel silicon-based drugs containing, a 4-silapiperidine or 4-silapiperidinium skeleton. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2004.08.023
• 作为产物：
  描述：

  2-(3-aminopropyl)-2-(4-fluorophenyl)[1,3]dioxolane 、 Bis-(2-bromethyl)-diphenylsilan 在 三乙胺 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 16.0h， 以67%的产率得到1-{3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl}-4,4-diphenyl-4-silapiperidine
  参考文献：
  名称：

  4-Silapiperidine and 4-silapiperidinium derivatives: syntheses and structural characterization

  摘要：

  A series of novel 4-silapiperidine and 4-silapiperidinium derivatives, with two silicon-bound aryl groups and various N-organyl groups, have been synthesized and structurally characterized (solution H-1, C-13, F-19, and Si-29 NMR spectroscopy; eight crystal structure analyses). These synthetic and structural investigations provide the basis for the development of novel silicon-based drugs containing, a 4-silapiperidine or 4-silapiperidinium skeleton. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2004.08.023

文献信息

• 4-Silapiperidine and 4-silapiperidinium derivatives: syntheses and structural characterization
  作者：Tilman Heinrich、Christian Burschka、Martin Penka、Brigitte Wagner、Reinhold Tacke

  DOI：10.1016/j.jorganchem.2004.08.023

  日期：2005.1

  A series of novel 4-silapiperidine and 4-silapiperidinium derivatives, with two silicon-bound aryl groups and various N-organyl groups, have been synthesized and structurally characterized (solution H-1, C-13, F-19, and Si-29 NMR spectroscopy; eight crystal structure analyses). These synthetic and structural investigations provide the basis for the development of novel silicon-based drugs containing, a 4-silapiperidine or 4-silapiperidinium skeleton. (C) 2004 Elsevier B.V. All rights reserved.