bis(4-(3,3-dimethyl-2-oxobutoxy)phenyl)diethylsilane | 1174552-99-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: bis(4-(3,3-dimethyl-2-oxobutoxy)phenyl)diethylsilane
• 英文别名: 1-[4-[[4-(3,3-Dimethyl-2-oxobutoxy)phenyl]-diethylsilyl]phenoxy]-3,3-dimethylbutan-2-one
• CAS: 1174552-99-8
• 化学式: C₂₈H₄₀O₄Si
• 分子量: 468.709
• InChiKey: CYIHDHRBFVTFCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.28
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  一氯频呐酮 、 bis(4-hydroxyphenyl)diethyllsilane 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以19%的产率得到bis(4-(3,3-dimethyl-2-oxobutoxy)phenyl)diethylsilane
  参考文献：
  名称：

  Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents

  摘要：

  Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC50: based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC50: based on reduction of viable cell number) values of 6.2-8.4 mu M and >100 mu M, respectively, in Madin-Darby bovine kidney (MDBK) cells infected with BVDV. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.137

文献信息

• Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents
  作者：Shinnosuke Hosoda、Hiroshi Aoyama、Yukinori Goto、Mohammed T.A. Salim、Mika Okamoto、Mariko Hashimoto、Masanori Baba、Yuichi Hashimoto

  DOI：10.1016/j.bmcl.2009.04.137

  日期：2009.6

  Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC50: based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC50: based on reduction of viable cell number) values of 6.2-8.4 mu M and >100 mu M, respectively, in Madin-Darby bovine kidney (MDBK) cells infected with BVDV. (C) 2009 Elsevier Ltd. All rights reserved.