(2S)-2-({[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]methyl}amino)-3-methyl-1,1-diphenyl-butan-1-ol | 956591-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-({[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]methyl}amino)-3-methyl-1,1-diphenyl-butan-1-ol
• 英文别名: (2S)-2-[[5-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-yl]methylamino]-3-methyl-1,1-diphenylbutan-1-ol
• CAS: 956591-00-7
• 化学式: C₃₀H₄₂N₂O₂Si
• 分子量: 490.761
• InChiKey: VDUJZZKSYQHEJV-NDEPHWFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.65
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  54.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S)-2-({[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]methyl}amino)-3-methyl-1,1-diphenyl-butan-1-ol 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以72%的产率得到(2S)-2-({[5-(hydroxymethyl)pyridin-2-yl]methyl}amino)-3-methyl-1,1-diphenylbutan-1-ol
  参考文献：
  名称：

  Enantioselective ethylation of aldehydes using a regenerable polymer-supported N-picolylvalinol tridentate ligand

  摘要：

  A supported pyridine-based tridentate chiral ligand has been prepared and evaluated for enantioselective addition of diethylzinc to aldehydes. The catalyst allowed the preparation of various chiral alcohols with the R configuration in good yields and enantiomeric excesses (up to 93%) and was found reusable. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.07.077
• 作为产物：
  描述：

  (S)-(-)-2-氨基-3-甲基-1,1-二苯基-1-丁醇 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 120.0h， 生成 (2S)-2-({[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]methyl}amino)-3-methyl-1,1-diphenyl-butan-1-ol
  参考文献：
  名称：

  Enantioselective ethylation of aldehydes using a regenerable polymer-supported N-picolylvalinol tridentate ligand

  摘要：

  A supported pyridine-based tridentate chiral ligand has been prepared and evaluated for enantioselective addition of diethylzinc to aldehydes. The catalyst allowed the preparation of various chiral alcohols with the R configuration in good yields and enantiomeric excesses (up to 93%) and was found reusable. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.07.077

文献信息

• Enantioselective ethylation of aldehydes using a regenerable polymer-supported N-picolylvalinol tridentate ligand
  作者：Vinciane Kelsen、Philippe Pierrat、Philippe C. Gros

  DOI：10.1016/j.tet.2007.07.077

  日期：2007.10

  A supported pyridine-based tridentate chiral ligand has been prepared and evaluated for enantioselective addition of diethylzinc to aldehydes. The catalyst allowed the preparation of various chiral alcohols with the R configuration in good yields and enantiomeric excesses (up to 93%) and was found reusable. (C) 2007 Elsevier Ltd. All rights reserved.