ethyl 2-(5-chloro-4-formyl-3-methyl-1H-pyrazol-1-yl)-3,3-bis(methylsulfanyl)acrylate | 263553-90-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-(5-chloro-4-formyl-3-methyl-1H-pyrazol-1-yl)-3,3-bis(methylsulfanyl)acrylate
• 英文别名: ethyl 2-(5-chloro-4-formyl-3-methylpyrazol-1-yl)-3,3-bis(methylsulfanyl)prop-2-enoate
• CAS: 263553-90-8
• 化学式: C₁₂H₁₅ClN₂O₃S₂
• 分子量: 334.848
• InChiKey: PXFUZRUUFOMHHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  二硫化碳 、 2-(5-氯-4-甲酰基-3-甲基吡唑-1-基)乙酸乙酯 、 碘甲烷 在 氢氧化钾 作用下， 以 二甲基亚砜 为溶剂， 反应 48.0h， 以54%的产率得到ethyl 2-(5-chloro-4-formyl-3-methyl-1H-pyrazol-1-yl)-3,3-bis(methylsulfanyl)acrylate
  参考文献：
  名称：

  一种合成吡唑并[5,1-b]噻唑的新方法

  摘要：

  摘要 通过1-吡唑乙酸乙酯与二硫化碳和碘甲烷的串联反应合成了吡唑并[5,1-b]噻唑。这是合成此类杂环的一种简单方法。

  DOI：

  10.1080/00397910008087378

文献信息

• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577B1

  公开（公告）日：2018-12-12
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• A Novel Method for the Synthesis of Pyrazolo[5,1-b]Thiazole
  作者：Zhongwen Wang、Jun Ren、Zhengming Li

  DOI：10.1080/00397910008087378

  日期：2000.2

  Abstract By a new tandem reaction, in which ethyl 1-pyrazolacetate reacted with carbon disulfide and iodomethane, pyrazolo[5,1-b]thiazole was synthesized. This was an easy method for the synthesis of this type of heterocyles.

  摘要 通过1-吡唑乙酸乙酯与二硫化碳和碘甲烷的串联反应合成了吡唑并[5,1-b]噻唑。这是合成此类杂环的一种简单方法。