2-(2'-bispyridin-2''-ylmethylaminophenyl)-4(3H)-quinazolinone | 1043896-65-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2'-bispyridin-2''-ylmethylaminophenyl)-4(3H)-quinazolinone
• 英文别名: 2-[2-[bis(pyridin-2-ylmethyl)amino]phenyl]-3H-quinazolin-4-one
• CAS: 1043896-65-6
• 化学式: C₂₆H₂₁N₅O
• 分子量: 419.486
• InChiKey: ZPZKWIRVGUTHFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  70.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(2-aminophenyl)quinazolin-4(3H)-one 、 2-氯甲基吡啶盐酸盐 在 potassium carbonate 、 potassium iodide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 168.0h， 以19%的产率得到2-(2'-bispyridin-2''-ylmethylaminophenyl)-4(3H)-quinazolinone
  参考文献：
  名称：

  Synthesis of dipicolylamino substituted quinazoline as chemosensor for cobalt(II) recognition based on excited-state intramolecular proton transfer

  摘要：

  A new fluorescent chemosensor for sensing Co(II) using di(2-picolyl)amino (DPA) as a recognition group and quinazoline as a reporting group has been synthesized and characterized. The quinazoline derivative contains an intramolecular hydrogen bond, which would undergo excited-state intramolecular proton transfer (ESIPT) at illumination. The fluorescence quenching is attributed to cation-induced inhibition of ESIPT, which constitutes the basis for the determination of Co(II) with the prepared chemosensor. The fluorophore forms 1:1 cobalt(II) complex with the logarithm of apparent dissociation constant log K-a = 6.8. The analytical performance characteristics of the proposed Co(II)-sensitive sensor were investigated. The chemosensor exhibits a linear response toward Co(II) in the concentration range 3.2 x 10(-8) to 1.4 x 10(-6) M, with a working pH range from 7.0 to 9.5 and high selectivity. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2007.09.012

文献信息

• Synthesis of dipicolylamino substituted quinazoline as chemosensor for cobalt(II) recognition based on excited-state intramolecular proton transfer
  作者：Hong-Yuan Luo、Xiao-Bing Zhang、Chun-Lian He、Guo-Li Shen、Ru-Qin Yu

  DOI：10.1016/j.saa.2007.09.012

  日期：2008.7

  A new fluorescent chemosensor for sensing Co(II) using di(2-picolyl)amino (DPA) as a recognition group and quinazoline as a reporting group has been synthesized and characterized. The quinazoline derivative contains an intramolecular hydrogen bond, which would undergo excited-state intramolecular proton transfer (ESIPT) at illumination. The fluorescence quenching is attributed to cation-induced inhibition of ESIPT, which constitutes the basis for the determination of Co(II) with the prepared chemosensor. The fluorophore forms 1:1 cobalt(II) complex with the logarithm of apparent dissociation constant log K-a = 6.8. The analytical performance characteristics of the proposed Co(II)-sensitive sensor were investigated. The chemosensor exhibits a linear response toward Co(II) in the concentration range 3.2 x 10(-8) to 1.4 x 10(-6) M, with a working pH range from 7.0 to 9.5 and high selectivity. (C) 2007 Elsevier B.V. All rights reserved.