(PhAcOZ-Leu-Cys-OAll)2 | 362626-20-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (PhAcOZ-Leu-Cys-OAll)2
• CAS: 362626-20-8
• 化学式: C₅₆H₆₆N₄O₁₄S₂
• 分子量: 1083.29
• InChiKey: KSKMEHYZIIKPQK-KVXOYYPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.77
• 重原子数：
  76.0
• 可旋转键数：
  31.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  240.06
• 氢给体数：
  4.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  (PhAcOZ-Leu-Cys-OAll)2 在 四(三苯基膦)钯 青霉素(酰胺)酶 、 1,3-二甲基巴比妥酸 、 DL-dithiothreitol 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 、 dimethyl-β-cyclodextrin 作用下， 以 四氢呋喃 、 甲醇 、 phosphate buffer 、 二氯甲烷 为溶剂， 反应 35.0h， 生成 H-Leu-Cys(CH2S-Pal)-Gly-OAll
  参考文献：
  名称：

  Mapping Concentration Profiles within the Diffusion Layer of an Electrode: Application to Redox Catalysis

  摘要：

  Catalytic reductions of some aromatic halides were performed at a millimetric electrode with several redox mediators. The resulting concentration profiles were monitored amperometrically by placing an ultramicroelectrode inside the diffusion layer produced at the former electrode. The features of redox catalysis and the subsequent structuring of the diffusion layer were investigated experimentally under steady-state conditions imposed by the spontaneous convection of the solution. The concentration profiles established from the probe measurements were in agreement with our theoretical predictions, based on fast kinetics of redox catalysis. Under these conditions, very similar to preparative electrosynthesis, the diffusion layer separates into two domains where pure diffusion takes place and the concentration profiles therein are mainly linear. We demonstrate that the limit between these two zones does not depend on kinetics, but is rather fixed by the product of the ratio of the bulk concentrations of each species and the ratio of their diffusion coefficients.

  DOI：

  10.1002/1521-3765(20010702)7:13<2940::aid-chem2940>3.0.co;2-u
• 作为产物：
  描述：

  O-(Trimethylsilyl)leucine 在 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.5h， 生成 (PhAcOZ-Leu-Cys-OAll)2
  参考文献：
  名称：

  Mapping Concentration Profiles within the Diffusion Layer of an Electrode: Application to Redox Catalysis

  摘要：

  Catalytic reductions of some aromatic halides were performed at a millimetric electrode with several redox mediators. The resulting concentration profiles were monitored amperometrically by placing an ultramicroelectrode inside the diffusion layer produced at the former electrode. The features of redox catalysis and the subsequent structuring of the diffusion layer were investigated experimentally under steady-state conditions imposed by the spontaneous convection of the solution. The concentration profiles established from the probe measurements were in agreement with our theoretical predictions, based on fast kinetics of redox catalysis. Under these conditions, very similar to preparative electrosynthesis, the diffusion layer separates into two domains where pure diffusion takes place and the concentration profiles therein are mainly linear. We demonstrate that the limit between these two zones does not depend on kinetics, but is rather fixed by the product of the ratio of the bulk concentrations of each species and the ratio of their diffusion coefficients.

  DOI：

  10.1002/1521-3765(20010702)7:13<2940::aid-chem2940>3.0.co;2-u