1N-(tert-butoxycarbonyl-6-aminohexanoyl)-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamine | 263762-44-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1N-(tert-butoxycarbonyl-6-aminohexanoyl)-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamine
• CAS: 263762-44-3
• 化学式: C₂₅H₄₀N₂O₁₂
• 分子量: 560.599
• InChiKey: FJGPKZXJAZKMOO-YDXQKAQTSA-N

物化性质

• 沸点：
  668.7±55.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.27
• 重原子数：
  39.0
• 可旋转键数：
  12.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  181.86
• 氢给体数：
  2.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  1N-(tert-butoxycarbonyl-6-aminohexanoyl)-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamine 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and characterisation of poly (l-lactic acid) galactosyl derivatives; access to functionalised microspheres

  摘要：

  A new series of galactosyl-derived polymers has been used for the preparation of microspheres, The strategy is based on the modification of the terminal carboxylic group L-PLA (73.000) by coupling to a galactosyl antenna in the presence of the peptide coupling agents: DCC/HOBT. The degree of functionalisation varies between 60 and 70%, and antenna density between 1.74 and 2,78, The characterisations of the new products were carried out using H-1 NMR, gel permeation chromatography, and acid base titration; the size of the functionalised microspheres was determined to be 210-270 mu m by DLS. (C) 2000 Published by Elsevier Science Ltd, All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02216-9
• 作为产物：
  描述：

  叔丁氧羰酰基6-氨基己酸 、 2,3,4,6-tetra-O-Acetyl-β-D-galactopyranosyl isothiocyanate 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以78%的产率得到1N-(tert-butoxycarbonyl-6-aminohexanoyl)-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamine
  参考文献：
  名称：

  Synthesis and characterisation of poly (l-lactic acid) galactosyl derivatives; access to functionalised microspheres

  摘要：

  A new series of galactosyl-derived polymers has been used for the preparation of microspheres, The strategy is based on the modification of the terminal carboxylic group L-PLA (73.000) by coupling to a galactosyl antenna in the presence of the peptide coupling agents: DCC/HOBT. The degree of functionalisation varies between 60 and 70%, and antenna density between 1.74 and 2,78, The characterisations of the new products were carried out using H-1 NMR, gel permeation chromatography, and acid base titration; the size of the functionalised microspheres was determined to be 210-270 mu m by DLS. (C) 2000 Published by Elsevier Science Ltd, All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02216-9