1-Benzyl 3,6,9,12,15-pentaoxadecanoate ester | 195071-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Benzyl 3,6,9,12,15-pentaoxadecanoate ester
• 英文别名: 14-hydroxy-3,6,9,12-tetraoxatetradecanoic acid phenylmethyl ester；Benzyl 14-hydroxy-3,6,9,12-tetraoxatetradecanoate；benzyl 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]acetate
• CAS: 195071-47-7
• 化学式: C₁₇H₂₆O₇
• 分子量: 342.389
• InChiKey: ZFHCLTHYABSRJT-UHFFFAOYSA-N

物化性质

• 沸点：
  462.7±40.0 °C(Predicted)
• 密度：
  1.151±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  24.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  83.45
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  1-Benzyl 3,6,9,12,15-pentaoxadecanoate ester 在 palladium on activated charcoal 吡啶 、 4-二甲氨基吡啶 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Molecular recognition induced aggregation and fusion between vesicles containing lipids bearing complementary hydrogen bonding head-groups

  摘要：

  大单层囊泡的等摩尔混合物，获自 鸡蛋卵磷脂和含有互补氢的脂质的混合物 结合头基（巴比妥酸和三氨基嘧啶），聚集体 并融合产生更大的囊泡。

  DOI：

  10.1039/a606340c
• 作为产物：
  描述：

  溴甲苯 在 4-甲基苯磺酸吡啶 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 49.0h， 生成 1-Benzyl 3,6,9,12,15-pentaoxadecanoate ester
  参考文献：
  名称：

  Cell uptake of a biosensor detected by hyperpolarized 129Xe NMR: The transferrin case

  摘要：

  For detection of biological events in vitro, sensors using hyperpolarized Xe-129 NMR can become a powerful tool, provided the approach can bridge the gap in sensitivity. Here we propose constructs based on the non-selective grafting of cryptophane precursors on holo-transferrin. This biological system was chosen because there are many receptors on the cell surface, and endocytosis further increases this density. The study of these biosensors with K562 cell suspensions via fluorescence microscopy and Xe-129 NMR indicates a strong interaction, as well as interesting features such as the capacity of xenon to enter the cryptophane even when the biosensor is endocytosed, while keeping a high level of polarization. Despite a lack of specificity for transferrin receptors, undoubtedly due to the hydrophobic character of the cryptophane moiety that attracts the biosensor into the cell membrane, these biosensors allow the first in-cell probing of biological events using hyperpolarized xenon. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.05.002

文献信息

• Selective Adhesion of Endothelial Cells to Artificial Membranes with a Synthetic RGD-Lipopeptide
  作者：Valérie Marchi-Artzner、Barbara Lorz、Ulrike Hellerer、Martin Kantlehner、Horst Kessler、Erich Sackmann

  DOI：10.1002/1521-3765(20010302)7:5<1095::aid-chem1095>3.0.co;2-b

  日期：2001.3.2

  incorporated into artificial membranes such as giant vesicles with DOPC and solid-supported lipid bilayers. The selective adhesion and spreading of endothelial cells of the human umbilical cord on solids functionalized by membranes with this RGD-lipopeptide have been observed. Furthermore, we have demonstrated strong selective adhesion of giant vesicles to endothelial cells through local adhesion domains

  已合成了受约束的环状ArgGly-Asp-D-Phe-Lys（缩写为环（-RGDfK-））脂肽，并将其掺入人工膜（如带有DOPC的巨型囊泡和固体支持的脂质双层）中。已经观察到人脐带内皮细胞在用该RGD-脂肽膜功能化的固体上的选择性粘附和扩散。此外，我们已经证明了通过结合流体动力流场和反射干涉对比显微镜（RICM）的应用，通过局部粘附域，巨泡对内皮细胞的强选择性粘附。通过与水溶性RGD肽竞争可以抑制粘附。我们建议这种策略可以提高脂质体靶向的效率，这些脂质体可用作载体或用作细胞的药物载体。
• [EN] Compounds<br/>[FR] COMPOSÉS
  申请人：[en]CARGENE THERAPEUTICS PTE. LTD.

  公开号：WO2023016999A2

  公开（公告）日：2023-02-16

  GalNAc monomers and GalNAc-oligonucleotide conjugates made using said GalNAc monomers, for example, GalNAc-bearing nucleic acids, e.g. sa-RNAs and siRNAs that may be useful in regulating expression of a target gene.