4,7,8,13-tetroxapentadecanoic acid | 257941-18-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4,7,8,13-tetroxapentadecanoic acid
• 英文别名: 4,7,10,13-Tetraoxapentadecanoic acid；3-[2-[2-(2-ethoxyethoxy)ethoxy]ethoxy]propanoic acid
• CAS: 257941-18-7
• 化学式: C₁₁H₂₂O₆
• 分子量: 250.292
• InChiKey: TYWIZUYMZDRVMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  366.2±32.0 °C(Predicted)
• 密度：
  1.087±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4,7,8,13-tetroxapentadecanoic acid 在 草酰氯 作用下， 以 二氯甲烷 为溶剂， 生成 4,7,10,13-tetroxapentadecanoyl chloride
  参考文献：
  名称：

  Bellouard, Frederic; Chuburu, Francoise; Yaouanc, Jean-Jaques, European Journal of Organic Chemistry, 1999, # 12, p. 3257 - 3261

  摘要：

  DOI：
• 作为产物：
  描述：

  三乙二醇乙醚 在 氢氧化钾 、 sodium ethanolate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 72.0h， 生成 4,7,8,13-tetroxapentadecanoic acid
  参考文献：
  名称：

  Bellouard, Frederic; Chuburu, Francoise; Yaouanc, Jean-Jaques, European Journal of Organic Chemistry, 1999, # 12, p. 3257 - 3261

  摘要：

  DOI：

文献信息

• [EN] CRYPTOPHYCIN-BASED ANTIBODY-DRUG CONJUGATES WITH NOVEL SELF-IMMOLATIVE LINKERS<br/>[FR] CONJUGUÉS MÉDICAMENT-ANTICORPS À BASE DE CRYPTOPHYCINE AVEC NOUVEAUX LIEURS AUTO-IMMOLABLES
  申请人：EXIRIS S R L

  公开号：WO2016146638A1

  公开（公告）日：2016-09-22

  The present invention relates to antibody- or peptide-drug conjugate compounds where one or more cryptophycin derivatives (macrocyclic depsipeptide) are covalently attached by a self-immolative linker which binds to one or more tumor-associated antigens or cell-surface receptors. The linker contains a cleavage site for proteases and a dipeptide unit able to form a diketopiperazine. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders, such as immune or infective diseases.

  本发明涉及抗体或肽药物结合物，其中一个或多个隐花链霉素衍生物（大环脱氨肽）通过一种自解离连接剂共价结合到一个或多个肿瘤相关抗原或细胞表面受体上。连接剂包含蛋白酶的裂解位点和能够形成二肽环的二肽单元。这些化合物可能在癌症的诊断或治疗方法以及其他疾病和紊乱，如免疫或感染性疾病中有用。
• [EN] DISCRETE PEG CONSTRUCTS<br/>[FR] CONSTRUCTIONS DE PEG DISCRÈTES
  申请人：EQUIP LLC

  公开号：WO2015023979A1

  公开（公告）日：2015-02-19

  Disclosed are linear discrete PEG constructs, which can be created and produced in a precise and reproducible way. Key to being able to do these things, where x in the discrete PEGX can vary from about 2 to about 64, is that the processes used to make each linear portion is controlled to give essentially one oligomer/one compound. Having a variable length linear discrete PEG construct that is (a) primarily an linear discrete PEG construct with diagnostic or therapeutic groups attached along a chain of attachment cores, which is attached to a preferential locator; (b) is an m-discrete PEG as the terminal construct on the linear portion, and "hidden"; (c) or linear discrete PEG with a terminus group that can be either negatively or positively charged, or neutral; and any of the discrete PEG portions can be designed to be cleaved after entering the cell.

  披露了线性离散PEG构造，可以以精确和可重复的方式创建和生产。能够做到这些的关键是，离散PEGX中的x可以在大约2到大约64之间变化，用于制造每个线性部分的过程被控制，以基本上提供一个寡聚体/一个化合物。具有可变长度的线性离散PEG构造，(a) 主要是具有连接诊断或治疗基团的沿着附着核心链附着的线性离散PEG构造，附着在优选定位器上; (b) 是线性部分上的末端构造的m-离散PEG，并且“隐藏”; (c) 或线性离散PEG，带有可以是负电荷、正电荷或中性的终端基团; 任何离散PEG部分都可以设计为进入细胞后被切割。
• ONIUM SALT, LIQUID COMPOSITION CONTAINING SAID ONIUM SALT AND CELLULOSE, AND CELLULOSE RECOVERY METHOD
  申请人：KOEI CHEMICAL COMPANY, LIMITED

  公开号：US20160009669A1

  公开（公告）日：2016-01-14

  The invention relates to an onium salt, a liquid composition containing the onium salt and cellulose, and a method for recovering cellulose. The invention makes it possible to provide an onium salt having an extremely high ability to dissolve cellulose at temperatures of 100° C. or lower. It also makes it possible to provide a liquid composition containing this onium salt and cellulose, as a composition suitable for the recovery of cellulose, and a method for recovering cellulose efficiently by using such a liquid composition containing the onium salt and cellulose.

  该发明涉及一种含有onium盐和纤维素的液体组合物以及一种恢复纤维素的方法。该发明使得能够在100°C或更低温度下提供具有极高溶解纤维素能力的onium盐成为可能。它还使得能够提供一种含有该onium盐和纤维素的液体组合物，作为适用于纤维素恢复的组合物，并通过使用含有onium盐和纤维素的这种液体组合物高效地恢复纤维素的方法成为可能。
• [EN] SELECTIVE SMALL MOLECULE DEGRADERS OF CEREBLON<br/>[FR] AGENTS DE DÉGRADATION DU CÉRÉBLON À PETITES MOLÉCULES SÉLECTIVES
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2021188537A1

  公开（公告）日：2021-09-23

  Disclosed are bispecific compounds (degraders) that target cereblon (CRBN) for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds as research tools and to reduce adverse side effects associated with a cereblon targeted therapy.

  披露了一种针对 cereblon (CRBN) 进行降解的双特异性化合物（降解剂）。还披露了含有这些降解剂的药物组合物，以及使用这些化合物作为研究工具和减少与 cereblon 靶向治疗相关的不良副作用的方法。
• Onium salt, liquid composition containing said onium salt and cellulose, and cellulose recovery method
  申请人：Koei Chemical Company, Limited

  公开号：US10087155B2

  公开（公告）日：2018-10-02

  The invention relates to an onium salt, a liquid composition containing the onium salt and cellulose, and a method for recovering cellulose. The invention makes it possible to provide an onium salt having an extremely high ability to dissolve cellulose at temperatures of 100° C. or lower. It also makes it possible to provide a liquid composition containing this onium salt and cellulose, as a composition suitable for the recovery of cellulose, and a method for recovering cellulose efficiently by using such a liquid composition containing the onium salt and cellulose.

  本发明涉及一种鎓盐、一种含有鎓盐和纤维素的液体组合物以及一种回收纤维素的方法。本发明可提供一种在 100° C 或更低温度下具有极高纤维素溶解能力的鎓盐。本发明还提供了一种含有这种鎓盐和纤维素的液体组合物，作为一种适用于回收纤维素的组合物，以及一种通过使用这种含有鎓盐和纤维素的液体组合物来高效回收纤维素的方法。