N-acryloyl-L-valine N'-methylamide | 303743-81-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-acryloyl-L-valine N'-methylamide
• 英文别名: (2S)-N,3-dimethyl-2-(prop-2-enoylamino)butanamide
• CAS: 303743-81-9
• 化学式: C₉H₁₆N₂O₂
• 分子量: 184.238
• InChiKey: CYSLVAFDGPVRCV-QMMMGPOBSA-N

物化性质

• 沸点：
  415.4±37.0 °C(Predicted)
• 密度：
  0.996±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  L-缬氨酸甲酯盐酸盐 在 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 30.33h， 生成 N-acryloyl-L-valine N'-methylamide
  参考文献：
  名称：

  通过RAFT聚合制备含氨基酸二酰胺衍生物的热敏聚合物。

  摘要：

  我们在此报告通过使用炔基官能化的2-十二烷基硫烷基硫基硫代羰基硫醚-2-基的可逆加成断裂链转移（RAFT）聚合反应合成定义明确的带有氨基酸二酰胺，聚N-丙烯酰基-L-缬氨酸N'-甲基酰胺的均聚物甲基丙酸炔丙醇酯为链转移剂（CTA），2,2'-偶氮二（异丁腈）为引发剂。研究了各种参数（例如温度和溶剂）对RAFT聚合的影响，以确定聚合的最佳控制。通过可控制的分子量和低分子量多分散指数（M w / Mn）所得的均聚物，并通过使用所得的聚合物作为大分子CTA并通过进一步的RAFT聚合成功形成了嵌段共聚物，以及通过“点击”化学反应成功地形成了嵌段共聚物，从而进一步证明了其保留了端基官能团。通过从UV /可见光谱法测量500nm下的透射率变化，根据水溶液中的较低临界溶液温度来评估所制备的聚合物的热响应性。©2010 Wiley Periodicals，Inc. J Polym Sci A部分：Polym

  DOI：

  10.1002/pola.24137

文献信息

• INHIBITOR OF BRUTON'S TYROSINE KINASE
  申请人：Beijing Reciprocapharmaceuticals Co., Ltd.

  公开号：EP3882241A1

  公开（公告）日：2021-09-22

  Disclosed herein is a compound of Formula (I) with a Btk inhibitory activity, wherein all the variables are as defined herein. The compound can be used for the treatment of diseases such as autoimmune diseases, xenogeneic immune diseases, cancers or thromboembolic diseases. Also disclosed is a pharmaceutical composition comprising a compound of Formula (I). Futher provided is a compound capable of inhibiting the activity of Bruton's tyrosine kinase by covalent binding.

  本文公开了一种具有 Btk 抑制活性的式 (I) 化合物，其中所有变量如本文所定义。该化合物可用于治疗自身免疫性疾病、异种免疫性疾病、癌症或血栓栓塞性疾病等疾病。还公开了一种包含式（I）化合物的药物组合物。还提供了一种能够通过共价结合抑制布鲁顿酪氨酸激酶活性的化合物。
• System for detecting rare cells
  申请人：The Regents of the University of Michigan

  公开号：US10317406B2

  公开（公告）日：2019-06-11

  A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.

  本发明公开了一种用于检测流体中稀有细胞的系统。该系统包括基底和置于基底上的混合物，混合物包括载体和用于捕获和释放稀有细胞的热响应聚合物。还公开了一种使用系统检测流体中稀有细胞的方法，该系统包括基底和放置在基底上的混合物。混合物包括载体和热响应聚合物。该方法包括提供该系统，并将含有稀有细胞的流体样品引入该系统，使样品与载体相互作用以捕获稀有细胞。
• System for Detecting Rare Cells
  申请人：The Regents of the University of Michigan

  公开号：US20160291019A1

  公开（公告）日：2016-10-06

  A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.
• INHIBITOR OF BRUTON TYROSINE KINASE
  申请人：BEIJING RECIPROCAPHARMACEUTICALS CO., LTD.

  公开号：US20220017484A1

  公开（公告）日：2022-01-20

  Disclosed herein is a compound of Formula (I) with a Btk inhibitory activity, wherein all the variables are as defined herein. The compound can be used for the treatment of diseases such as autoimmune diseases, xenogeneic immune diseases, cancers or thromboembolic diseases. Also disclosed is a pharmaceutical composition comprising a compound of Formula (I). Further provided is a compound capable of inhibiting the activity of Bruton's tyrosine kinase by covalent binding.
• Preparation of thermoresponsive polymers bearing amino acid diamide derivatives via RAFT polymerization
  作者：Zhilei Liu、Jiwen Hu、Jianping Sun、Guping He、Yinghui Li、Ganwei Zhang

  DOI：10.1002/pola.24137

  日期：2010.8.15

  We report here the synthesis of well‐defined homopolymer bearing amino acid diamide, poly(N‐acryloyl‐L‐valine N′‐methylamide), via reversible addition fragmentation chain transfer (RAFT) polymerization using alkynyl‐functionalized 2‐dodecylsulfanylthiocarbonylsulfanyl‐2‐methyl‐propionic acid propargyl alcohol ester as chain transfer agent (CTA) and 2,2′‐azobis(isobutyronitrile) as initiator. The effects

  我们在此报告通过使用炔基官能化的2-十二烷基硫烷基硫基硫代羰基硫醚-2-基的可逆加成断裂链转移（RAFT）聚合反应合成定义明确的带有氨基酸二酰胺，聚N-丙烯酰基-L-缬氨酸N'-甲基酰胺的均聚物甲基丙酸炔丙醇酯为链转移剂（CTA），2,2'-偶氮二（异丁腈）为引发剂。研究了各种参数（例如温度和溶剂）对RAFT聚合的影响，以确定聚合的最佳控制。通过可控制的分子量和低分子量多分散指数（M w / Mn）所得的均聚物，并通过使用所得的聚合物作为大分子CTA并通过进一步的RAFT聚合成功形成了嵌段共聚物，以及通过“点击”化学反应成功地形成了嵌段共聚物，从而进一步证明了其保留了端基官能团。通过从UV /可见光谱法测量500nm下的透射率变化，根据水溶液中的较低临界溶液温度来评估所制备的聚合物的热响应性。©2010 Wiley Periodicals，Inc. J Polym Sci A部分：Polym