N,N-dimethyl-3-(trifluoromethoxy)benzenesulfonamide | 1263275-51-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dimethyl-3-(trifluoromethoxy)benzenesulfonamide
• CAS: 1263275-51-9
• 化学式: C₉H₁₀F₃NO₃S
• mdl: MFCD18426358
• 分子量: 269.245
• InChiKey: WRBWBIYKZMIJOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-(三氟甲氧基)苯硼酸 在 phenylchlorosulfate 、 C₄₃H₄₃NO₃PPdS 、 sodium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 12.0h， 生成 N,N-dimethyl-3-(trifluoromethoxy)benzenesulfonamide
  参考文献：
  名称：

  钯催化芳基硼酸氯磺酰化合成芳基磺酰胺

  摘要：

  描述了一种用于制备磺酰胺的钯催化方法。该工艺表现出显着的官能团耐受性，并允许在温和条件下制备多种芳基磺酰氯和磺酰胺。

  DOI：

  10.1021/ja405949a

文献信息

• Simple N , N- dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models
  作者：Tomoyuki Tanaka、Nana Yajima、Tomoko Kiyoshi、Yoshiki Miura、Seiji Iwama

  DOI：10.1016/j.bmcl.2016.11.035

  日期：2017.1

  Optimization of the previously reported benzothiazine analogue A led to the identification of compound 1, which showed anti-convulsant activity in two golden standard animal models of seizure, the MES and scPTZ models. Structure-activity relationship investigation of compound 1 revealed compounds 2, 6 and 19 as attractive anti-epileptic drug (AED) candidates with potent anticonvulsant effect in both the MES and scPTZ models. As these compounds are structurally different from existing AEDs, determination of their mechanism of actions could provide clues to understanding current therapy-resistant seizures. Moreover, these simple phenylsulfoneamide compounds could be good starting points for searching broad spectrum AEDs by such in vivo screening. (C) 2016 Elsevier Ltd. All rights reserved.
• Synthesis of Aryl Sulfonamides via Palladium-Catalyzed Chlorosulfonylation of Arylboronic Acids
  作者：J. Robb DeBergh、Nootaree Niljianskul、Stephen L. Buchwald

  DOI：10.1021/ja405949a

  日期：2013.7.24

  A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.

  描述了一种用于制备磺酰胺的钯催化方法。该工艺表现出显着的官能团耐受性，并允许在温和条件下制备多种芳基磺酰氯和磺酰胺。