2-氨基-3,5-二氰基-6-羟基-4-苯基吡啶 | 67720-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氨基-3,5-二氰基-6-羟基-4-苯基吡啶
• 英文名称: 2-amino-3,5-dicyano-5-hydroxy-4-phenylpyridine
• 英文别名: 2-amino-3,5-dicyano-6-hydroxy-4-phenylpyridine；2-hydroxy-6-amino-4-phenylpyridine-3,5-dicarbonitrile；6-Amino-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile；2-amino-6-oxo-4-phenyl-1H-pyridine-3,5-dicarbonitrile
• CAS: 67720-42-7
• 化学式: C₁₃H₈N₄O
• 分子量: 236.233
• InChiKey: VDIPUISMFIDXRX-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(Solv: ethanol (64-17-5); N,N-dimethylformamide (68-12-2))
• 沸点：
  414.6±45.0 °C(Predicted)
• 密度：
  1.40±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氨基-3,5-二氰基-6-羟基-4-苯基吡啶 在 五氯化磷 、 三氯氧磷 作用下， 反应 24.0h， 以33%的产率得到2-氨基-6-氯-4-苯基-吡啶-3,5-二甲腈
  参考文献：
  名称：

  Peinador, Carlos; Veiga, M. Carmen; Vilar, Juan, Heterocycles, 1994, vol. 38, # 6, p. 1299 - 1306

  摘要：

  DOI：
• 作为产物：
  描述：

  2-amino-6-(2-amino-phenylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以55%的产率得到2-氨基-3,5-二氰基-6-羟基-4-苯基吡啶
  参考文献：
  名称：

  Synthetic Studies Using α,β-Unsaturated Nitriles: Facile Synthesis of Pyridine Derivatives

  摘要：

  DOI：

  10.1055/s-1981-29513

文献信息

• HETEROARYL-SUBSTITUTED DICYANOPYRIDINES AND THEIR USE
  申请人：Meibom Daniel

  公开号：US20110207698A1

  公开（公告）日：2011-08-25

  The present application relates to novel heteroaryl-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新颖的杂环芳基取代的二氰基吡啶，以及它们的制备方法，用于治疗和/或预防疾病的用途，以及用于制备治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。
• SUBSTITUTED ARYLOXAZOLES AND THEIR USE
  申请人：Nell Peter

  公开号：US20110130377A1

  公开（公告）日：2011-06-02

  The present application relates to novel substituted aryloxazole derivatives, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases and the use thereof for the production of drugs for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.

  本申请涉及新型取代芳氧唑衍生物，其生产方法，用于治疗和/或预防疾病的用途，以及用于生产用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管和代谢紊乱。
• 2-ALKOXY-SUBSTITUTED DICYANOPYRIDINES AND THEIR USE
  申请人：Hübsch Walter

  公开号：US20110136871A1

  公开（公告）日：2011-06-09

  The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新型2-烷氧基取代的二氰基吡啶，其制备过程，其用于治疗和/或预防疾病的用途，以及其用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• CYCLOALKOXY-SUBSTITUTED 4-PHENYL-3,5-DICYANOPYRIDINES AND THEIR USE
  申请人：Hübsch Walter

  公开号：US20110021487A1

  公开（公告）日：2011-01-27

  The present application relates to novel cycloalkoxy-substituted 4-phenyl-3,5-dicyanopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.

  本申请涉及新型环烷氧基取代的4-苯基-3,5-二氰基吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途以及其用于制备治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管和代谢性疾病。
• An efficient and greener approach to the synthesis of 3,5-dicyanopyridin-2(1<i>H</i>)-one derivatives in aqueous media under microwave irradiation conditions
  作者：Runhong Jia、Shujiang Tu、Yan Zhang、Bo Jiang、Junyong Zhang、Changsheng Yao、Feng Shi

  DOI：10.1002/jhet.5570440533

  日期：2007.9

  A facile and greener synthesis of a series of 3,5-dicyanopyridin-2(1H)-one derivatives was accomplished via the one-pot reaction of aldehyde, malononitrile and sodium hydroxide in aqueous media under microwave irradiation. This method had several advantages such as shorter route and time, lower cost, reduced environmental impact.

  一系列3,5-dicyanopyridin-2（1 H）-one衍生物的简便，绿色合成是通过在微波辐射下，醛，丙二腈和氢氧化钠在水性介质中的一锅反应完成的。该方法具有许多优点，例如路线和时间较短，成本较低，对环境的影响较小。