(1-氟环戊基)甲胺盐酸盐 | 1462885-83-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: (1-氟环戊基)甲胺盐酸盐
• 英文名称: 1-aminomethyl-1-fluorcyclopentane hydrochloride
• 英文别名: (1-Fluorocyclopentyl)methanamine hydrochloride；(1-fluorocyclopentyl)methanamine;hydrochloride
• CAS: 1462885-83-1
• 化学式: C₆H₁₂FN*ClH
• 分子量: 153.627
• InChiKey: SNPRUEFPTXDJEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.65
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1-氟环戊基)甲胺盐酸盐 、 苯甲酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 1.17h， 以55%的产率得到N-[(1-fluorocyclopentyl)methyl]benzamide
  参考文献：
  名称：

  A convenient approach towards the 1-aminomethyl-1-fluorocycloalkane scaffold

  摘要：

  A three-step synthesis towards 1-aminomethy1-1-fluorocycloalkanes was developed starting from methylenecycloalkanes. Methylenecyclobutane, methylenecyclopentane and methylenecyclohexane were first bromofluorinated to provide the corresponding Markovnikov products, 1-bromomethy1-1-fluorocycloalkanes, which were then converted towards the title compound via azide substitution and hydrogenation. The bromofluorination of methylenecyclopropane, however, led to both the Markovnikov and the anti-Markovnikov product. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.127
• 作为产物：
  描述：

  1-(bromomethyl)-1-fluorocyclopentane 在 sodium azide 、 palladium on carbon 、 氢气 、 sodium iodide 作用下， 以 二甲基亚砜 、 乙酸乙酯 为溶剂， 20.0~100.0 ℃ 、500.01 kPa 条件下， 反应 32.17h， 生成 (1-氟环戊基)甲胺盐酸盐
  参考文献：
  名称：

  A convenient approach towards the 1-aminomethyl-1-fluorocycloalkane scaffold

  摘要：

  A three-step synthesis towards 1-aminomethy1-1-fluorocycloalkanes was developed starting from methylenecycloalkanes. Methylenecyclobutane, methylenecyclopentane and methylenecyclohexane were first bromofluorinated to provide the corresponding Markovnikov products, 1-bromomethy1-1-fluorocycloalkanes, which were then converted towards the title compound via azide substitution and hydrogenation. The bromofluorination of methylenecyclopropane, however, led to both the Markovnikov and the anti-Markovnikov product. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.127

文献信息

• [EN] NOVEL TRIAZINE DERIVATIVE<br/>[FR] NOUVEAU DÉRIVÉ DE TRIAZINE<br/>[JA] 新規トリアジン誘導体
  申请人：MEIJI SEIKA PHARMA CO LTD

  公开号：WO2021066088A1

  公开（公告）日：2021-04-08

  ヒスタミンＨ４受容体の調節作用を有し、ヒスタミンＨ４受容体が関与する疾患若しくは状態の治療及び／又は予防に有用な、下記式（１）で表される化合物及びその薬理学的に許容される塩、これらの使用、並びに、これらを含有する医薬組成物を提供する。
• A convenient approach towards the 1-aminomethyl-1-fluorocycloalkane scaffold
  作者：Matthias Moens、Matthias D’hooghe、Norbert De Kimpe

  DOI：10.1016/j.tetlet.2013.08.127

  日期：2013.11

  A three-step synthesis towards 1-aminomethy1-1-fluorocycloalkanes was developed starting from methylenecycloalkanes. Methylenecyclobutane, methylenecyclopentane and methylenecyclohexane were first bromofluorinated to provide the corresponding Markovnikov products, 1-bromomethy1-1-fluorocycloalkanes, which were then converted towards the title compound via azide substitution and hydrogenation. The bromofluorination of methylenecyclopropane, however, led to both the Markovnikov and the anti-Markovnikov product. (C) 2013 Elsevier Ltd. All rights reserved.