(cyclohexyl-N-thio)-1,2-ethylenediamine | 959755-05-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 英文名称: (cyclohexyl-N-thio)-1,2-ethylenediamine
• 英文别名: 1-(2-Aminoethyl)-3-cyclohexylthiourea
• CAS: 959755-05-6
• 化学式: C₉H₁₉N₃S
• 分子量: 201.336
• InChiKey: XLCXRHUQFJFGRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (cyclohexyl-N-thio)-1,2-ethylenediamine 、 nickel diacetate 以 盐酸 、 甲醇 为溶剂， 生成 bis[(cyclohexyl-N-thio)-1,2-ethylenediamine]nickel(II) diacetate
  参考文献：
  名称：

  Synthesis, characterization, and antifungal and antibacterial studies of nickel(II)thiodiamine complexes

  摘要：

  Nickel(II) complexes of type [Ni(L)(2)Cl-2] and [Ni(L)(2)(OCOCH3)(2)], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L-1) and (cyclohexyl-N-thio)-1,3-propanediamine (L-2) has been synthesized and characterized by elemental analysis, FT-IR, mass, UV-Vis, and H-1 NMR spectroscopic studies. The thiodiamines coordinate as a bidentate N-S ligand. The ratio of the metal: ligand was 1: 2 for all the complexes. The binding sites are the azomethine nitrogen and thioamide sulfur. The complexes are found to be soluble in acetone, dimethylformamide, and dimethylsulfoxide. All the complexes were found amorphous in nature. Molar conductance values in DMSO indicate the nonelectrolyte nature of the complexes. In vitro antifungal and in vitro antibacterial studies were performed against fungal and bacterial strains, Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger, and Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, respectively. Preliminary antimicrobial screening shows the good results against both the fungal and the bacterial strains, which can lead through the investigation of better drug.

  DOI：

  10.1134/s1070328409040101
• 作为产物：
  描述：

  二硫化碳 、 环己胺 、 乙二胺 在 氢氧化钾 作用下， 以 甲醇 、 水 为溶剂， 反应 0.75h， 生成 (cyclohexyl-N-thio)-1,2-ethylenediamine
  参考文献：
  名称：

  硫代二胺的一些新的铂（IV）和钯（II）配合物的合成，表征，细胞毒性，抗菌和抗真菌评估。

  摘要：

  [Pt（L）2Cl2]和[Pd（L）Cl2]类型的一些新的铂（IV）和钯（II）硫代二胺络合物，其中[L =（环己基-N-硫代）-1,2-乙二胺（ L（1））和（环己基-N-硫基）-1,3-丙二胺（L（2））]已合成。硫代二胺作为双齿NS配体配位。硫代二胺的合成铂（IV）和钯（II）配合物通过元素分析，IR，质量，电子和（1）H NMR光谱学表征。还对这些复合物的细胞毒性，体外抗真菌和体外抗菌活性进行了筛选。还评估了一种复合物的脱水和分解反应的热力学参数，例如活化能（Ea），表观活化熵（S（＃））和焓变（DeltaH）。

  DOI：

  10.1016/j.ejmech.2007.03.017

文献信息

• Synthesis, characterization, and antifungal and antibacterial studies of nickel(II)thiodiamine complexes
  作者：A. K. Mishra、S. B. Mishra、N. K. Kaushik

  DOI：10.1134/s1070328409040101

  日期：2009.4

  Nickel(II) complexes of type [Ni(L)(2)Cl-2] and [Ni(L)(2)(OCOCH3)(2)], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L-1) and (cyclohexyl-N-thio)-1,3-propanediamine (L-2) has been synthesized and characterized by elemental analysis, FT-IR, mass, UV-Vis, and H-1 NMR spectroscopic studies. The thiodiamines coordinate as a bidentate N-S ligand. The ratio of the metal: ligand was 1: 2 for all the complexes. The binding sites are the azomethine nitrogen and thioamide sulfur. The complexes are found to be soluble in acetone, dimethylformamide, and dimethylsulfoxide. All the complexes were found amorphous in nature. Molar conductance values in DMSO indicate the nonelectrolyte nature of the complexes. In vitro antifungal and in vitro antibacterial studies were performed against fungal and bacterial strains, Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger, and Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, respectively. Preliminary antimicrobial screening shows the good results against both the fungal and the bacterial strains, which can lead through the investigation of better drug.
• Synthesis, characterization, cytotoxicity, antibacterial and antifungal evaluation of some new platinum (IV) and palladium (II) complexes of thiodiamines
  作者：A.K. Mishra、N.K. Kaushik

  DOI：10.1016/j.ejmech.2007.03.017

  日期：2007.10

  Some new platinum (IV) and palladium (II) thiodiamine complexes of type [Pt(L)2Cl2] and [Pd(L)Cl2], [where, L=(cyclohexyl-N-thio)-1,2-ethylenediamine (L(1)) and (cyclohexyl-N-thio)-1,3-propanediamine (L(2))] have been synthesized. The thiodiamines coordinate as a bidentate N-S ligand. The synthesized platinum (IV) and palladium (II) complexes of the thiodiamines were characterized by elemental analysis

  [Pt（L）2Cl2]和[Pd（L）Cl2]类型的一些新的铂（IV）和钯（II）硫代二胺络合物，其中[L =（环己基-N-硫代）-1,2-乙二胺（ L（1））和（环己基-N-硫基）-1,3-丙二胺（L（2））]已合成。硫代二胺作为双齿NS配体配位。硫代二胺的合成铂（IV）和钯（II）配合物通过元素分析，IR，质量，电子和（1）H NMR光谱学表征。还对这些复合物的细胞毒性，体外抗真菌和体外抗菌活性进行了筛选。还评估了一种复合物的脱水和分解反应的热力学参数，例如活化能（Ea），表观活化熵（S（＃））和焓变（DeltaH）。