4-bromobutyl propionate | 35161-90-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-bromobutyl propionate
• 英文别名: Propionsaeure-<4-brom-butylester>；4-Bromobutyl propanoate
• CAS: 35161-90-1
• 化学式: C₇H₁₃BrO₂
• 分子量: 209.083
• InChiKey: YFNHCYVGTKEHMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  224.1±23.0 °C(Predicted)
• 密度：
  1.300±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-bromobutyl propionate 在 正丁基锂 、 五氯化磷 、 thallium (I) ethoxide 、 sodium hydride 、 二异丙胺 作用下， 以 乙醚 为溶剂， 反应 0.5h， 生成 norethisterone 2,2-dimethyl-6-propanoyloxyhexanoate
  参考文献：
  名称：

  Long-acting contraceptive agents: Esters of norethisterone with α- and/or β-chain branching

  摘要：

  The synthesis of eighteen esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) is described. These all possess some form of alpha- and/or beta-substitution in the ester side-chain. The work was undertaken in order to evaluate any long-acting fertility control effect intrinsic in such compounds. A pentamethyl disiloxy ether was also included in the group of substances prepared for testing because of its similar substitution pattern.

  DOI：

  10.1016/0039-128x(83)90096-x

文献信息

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  公开号：US20140107351A1

  公开（公告）日：2014-04-17

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• Novel Cannabinergic Compounds and Uses Thereof
  申请人：Northeastern University

  公开号：US20160108016A1

  公开（公告）日：2016-04-21

  Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. This disclosure is directed to methods of treating cannabinoid dependence, neuropathy, inflammation, glaucoma, a neurodegenerative disorder, a motor function disorder, a gastrointestinal disorder, hypothermia, emesis, loss of appetite, or anorexia associated with AIDS.

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  DOI：10.1002/adsc.202300450

  日期：2023.7.4

  Herein, we report a direct method to prepare alkylzinc compounds from functionalized alkyl bromides using cobalt catalysis under mild conditions. This procedure only requires a simple catalytic system composed of CoBr2 and bipyridine as ligand in a mixture of acetonitrile/pyridine. This reaction is stable under air and moisture conditions opening the way to an accessible procedure. A wide range of

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• LINEAR BLOCK POLYMER COMPRISING UREA AND URETHANE GROUPS, METHOD FOR THE PRODUCTION OF LINEAR BLOCK POLYMERS AND USE OF THE BLOCK POLYMERS AS IMPLANTS
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  公开号：EP0866816A1

  公开（公告）日：1998-09-30
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