(2RS)-fluorododecanoic acid | 10457-84-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2RS)-fluorododecanoic acid
• 英文别名: 2-fluorododecanoic acid；Fluorododecanoic acid
• CAS: 10457-84-8
• 化学式: C₁₂H₂₃FO₂
• 分子量: 218.312
• InChiKey: YGTMNOGMVCWVAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2RS)-fluorododecanoic acid 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 6-<4-deoxy-4-<(2RS)-fluorododecanoyl>glycylamino-L-glycero-β-L-manno-heptapyranosylamino>-9H-purine
  参考文献：
  名称：

  Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives.

  摘要：

  新合成了一系列在分子脂肪酸部分进行了修饰的斯匹卡霉素衍生物，并研究了它们的构效关系。通过对脂肪酸部分进行修饰，将其转化为十四碳二烯酸或十二碳二烯酸类似物，这些衍生物对COL-1人结肠癌异种移植模型的抗肿瘤活性显著优于SPM VIII。

  DOI：

  10.7164/antibiotics.48.1467
• 作为产物：
  描述：

  正癸基丙二酸二乙酯 在 盐酸 作用下， 生成 (2RS)-fluorododecanoic acid
  参考文献：
  名称：

  有机氟化合物。二。2-氟脂肪酸的合成及其抗真菌性能。

  摘要：

  DOI：

  10.1021/jm00314a013

文献信息

• PREPARATION AND SYNTHETIC UTILITY OF DIFLUOROKETENE THIOACETAL. A NOVEL SYNTHETIC ROUTE TOα-MONOFLUOROALKANOIC ACIDS
  作者：Kiyoshi Tanaka、Takeshi Nakai、Nobuo Ishikawa

  DOI：10.1246/cl.1979.175

  日期：1979.2.5

  Difluoroketene thioacetal (2) prepared from trifluoroacetaldehyde thioacetal (3) with lithium diisopropylamide or alkyllithiums has been shown to be useful as a building block for the preparation of α-monofluoroalkanoic acids (5), which involves the reaction of 2 with various organometallic compounds followed by hydrolysis of the resulting monofluoroketene thioacetal (4).

  由三氟乙醛硫缩醛 (3) 与二异丙基氨基锂或烷基锂制备的二氟乙烯酮硫缩醛 (2) 已被证明可用作制备 α-单氟链烷酸 (5) 的结构单元，其中涉及 2 与各种有机金属化合物的反应，然后通过水解生成的单氟乙烯酮硫缩醛 (4)。
• Spicamycin derivatives and the use thereof
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP0525479B1

  公开（公告）日：1997-11-05
• JPS6079069A
  申请人：——

  公开号：JPS6079069A

  公开（公告）日：1985-05-04
• Image display medium, process for forming image, and multicolor image-forming apparatus
  申请人：——

  公开号：US20030184644A1

  公开（公告）日：2003-10-02

  An image display medium that includes a photoconductive layer containing a photochromic compound and an electron accepting compound; and a substrate, in which the photochromic compound contains a fulgide compound, and the electron accepting compound contains a compound selected at least from: a) a phosphonic acid compound having an aliphatic group containing 12 or more carbon atoms; b) an aliphatic carboxylic acid compound having an aliphatic group containing 12 or more carbon atoms; and c) a phenolic compound having an aliphatic group containing 12 or more carbon atoms, a process for forming an image using the medium, and a multicolor image-forming apparatus using the medium and suitable for the process.
• SURFACTANT
  申请人：Suzuki Kazumitsu

  公开号：US20070167343A1

  公开（公告）日：2007-07-19

  To provide a surfactant which is obtainable by using substantially no alkali metal, has excellent readhesion prevention ability of finely-pulverized particles at the time of cleaning, and is capable of quite efficient and advanced cleaning. In the present invention, a surfactant which comprises a neutralized salt (AB1) and/or neutralized salt (AB2) is used. Neutralized salt (AB1): a neutralized salt (AB1) which comprises an acidic compound (A1) containing at least each one of an acid group (X1) of an acid having the difference of heat of formation in an acid dissociation reaction (Q1) of 3 to 200 kcal/mol and a hydrophobic group (Y) containing 1 to 36 carbon atoms, and a nitrogen-containing basic compound (B) having the difference of heat of formation in a proton addition reaction of 10 to 152 kcal/mol, wherein (X1) is at least one species selected from a sulfonic acid group, and the like. Neutralized salt (AB2): a neutralized salt (AB2) which comprises a polymer (A2) having at least one acid group (X2) within the molecule, and the nitrogen-containing basic compound (B) having the difference of heat of formation in a proton addition reaction of 10 to 152 kcal/mol.