10-ethoxy-2,3,5,6,7,8-hexahydro-1H-phenanthren-4-one | 855366-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 10-ethoxy-2,3,5,6,7,8-hexahydro-1H-phenanthren-4-one
• 英文别名: 10-Aethoxy-2,3,5,6,7,8-hexahydro-1H-phenanthren-4-on
• CAS: 855366-80-2
• 化学式: C₁₆H₂₀O₂
• 分子量: 244.334
• InChiKey: OLNXRSRLTYCTMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.48
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  10-ethoxy-2,3,5,6,7,8-hexahydro-1H-phenanthren-4-one 在 盐酸 、 amalgamated zinc 、 甲苯 作用下， 生成 ethyl-(1,2,3,4,5,6,7,8-octahydro-[9]phenanthryl)-ether
  参考文献：
  名称：

  Ssergijewsskaja; Danilowa, Zhurnal Obshchei Khimii, 1946, vol. 16, p. 1077,1080, 1081

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(3-ethoxy-5,6,7,8-tetrahydro-[2]naphthyl)-butyric acid 在 phosphorus pentoxide 、 甲苯 作用下， 生成 10-ethoxy-2,3,5,6,7,8-hexahydro-1H-phenanthren-4-one
  参考文献：
  名称：

  Ocular surface changes induced by topical application of latanoprost and timolol: a short-term study in glaucomatous patients with and without allergic conjunctivitis

  摘要：

  Background: This study evaluated the conjunctival effects of latanoprost and timolol. both of which contain benzalkonium. chloride, in patients with primary open-angle glaucoma (POAG), with and without a history of allergic conjunctivitis (AC). Methods: Two groups of 25 patients with and without a positive history for AC were studied. After a 21-day wash-out period patients were randomized to 14 days treatment with latanoprost or with timolol, in a cross-over fashion. The following parameters were evaluated on days 0 and 14: number of white blood cells, ferning test. conjunctival impression cytology, subjective symptoms, and objective ocular changes. Results: Latanoprost caused: (a) an increase in eosinophils in both groups and reduction in lymphocytes only in the group with a history of AC; (b) alterations in ferning test and impression cytology only in AC patients; and (c) development of subjective symptoms and objective signs only in non-AC glaucomatous subjects. Timolol therapy was responsible only for the occurrence of subjective symptoms and objective signs in non-AC patients. Conclusion: Latanoprost treatment induces ocular surface changes which are more evident in POAG patients who are also affected by AC. These findings are probably related to the very high latanoprost concentration of benzalkonium chloride and to its bedtime administration, which further amplifies the toxicity.

  DOI：

  10.1007/s004170100328