8-Amino-5H-dibenzo<1.4>diazepin-11(10H)-one | 3604-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 8-Amino-5H-dibenzo<1.4>diazepin-11(10H)-one
• 英文别名: 8-amino-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-11-one；8-amino-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one；8-Amino-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-on；8-amino-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one；3-amino-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one
• CAS: 3604-56-6
• 化学式: C₁₃H₁₁N₃O
• 分子量: 225.25
• InChiKey: SQYHCBVSGAJWNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-Amino-5H-dibenzo<1.4>diazepin-11(10H)-one 在 五氯化磷 作用下， 以 苯 为溶剂， 生成
  参考文献：
  名称：

  Triazolo derivatives of dibenzodiazepines as potential c.n.s. Active drug

  摘要：

  The synthesis of a number of substituted triazolo derivatives of Dibenzodiazepines are reported. The medicinal properties were evaluated through various pharmacological assessments applied on albino mice of either sex taking clozapine as standard drug. A triazolo derivatives having substitution at 8-positions Dibenzodiazepines was found to have for better CNS depressant activity properties as compared to the basic Dibenzodiazepines moeity and among other 8-subsituted derivatives amino substitution exhibited 70 - 80 % antiepileptic properties.

  DOI：

  10.1515/hc.2009.15.2.141
• 作为产物：
  描述：

  N-(2,4-diamino-phenyl)-anthranilic acid 以 邻二甲苯 为溶剂， 生成 8-Amino-5H-dibenzo<1.4>diazepin-11(10H)-one
  参考文献：
  名称：

  Triazolo derivatives of dibenzodiazepines as potential c.n.s. Active drug

  摘要：

  The synthesis of a number of substituted triazolo derivatives of Dibenzodiazepines are reported. The medicinal properties were evaluated through various pharmacological assessments applied on albino mice of either sex taking clozapine as standard drug. A triazolo derivatives having substitution at 8-positions Dibenzodiazepines was found to have for better CNS depressant activity properties as compared to the basic Dibenzodiazepines moeity and among other 8-subsituted derivatives amino substitution exhibited 70 - 80 % antiepileptic properties.

  DOI：

  10.1515/hc.2009.15.2.141

文献信息

• 6. Chemotherapeutic studies in the acridine series. Part III. 4-Amino-, 1 : 3-, 1 : 7-, and 3 : 6-diaminoacridines
  作者：Adrien Albert、Wilfred H. Linnell

  DOI：10.1039/jr9380000022

  日期：——
• SAHNI S.; GROVER R.; TYAGI R. P.; JOSHI B. C.; BARAR F. S. K., J. INDIAN CHEM. SOC., 1979, 56, NO 6, 625-626
  作者：SAHNI S.、 GROVER R.、 TYAGI R. P.、 JOSHI B. C.、 BARAR F. S. K.

  DOI：——

  日期：——