(+)-(5S)-2-(trans-styryl)-5-(4-methoxyphenyl)-Δ2-oxazoline | 1122469-32-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (+)-(5S)-2-(trans-styryl)-5-(4-methoxyphenyl)-Δ2-oxazoline
• 英文别名: shahidine；(5R)-5-(4-methoxyphenyl)-2-[(E)-2-phenylethenyl]-4,5-dihydro-1,3-oxazole
• CAS: 1122469-32-2
• 化学式: C₁₈H₁₇NO₂
• 分子量: 279.338
• InChiKey: JWIXCXBFPMKPIN-CRVDFBCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  30.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+)-(5S)-2-(trans-styryl)-5-(4-methoxyphenyl)-Δ2-oxazoline 在 水 作用下， 生成 2-propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)
  参考文献：
  名称：

  Shahidine, a novel and highly labile oxazoline from Aegle marmelos: the parent compound of aegeline and related amides

  摘要：

  A rare alkaloid, shahidine (1), having an unstable oxazoline core has been isolated as a major constituent from the fresh leaves of Aegle marmelos. It is moisture-sensitive, and found to be the parent compound of aegeline and other amides, however. it is stable in dimethyl sulfoxide. Its structure was established by spectroscopic analysis. Biogenetically, oxazolines may be considered as the precursor of hydroxy amides and oxazoles found in plants. Shahidine (1) showed activity against a few Gram-positive bacteria. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.11.088

文献信息

• Shahidine, a novel and highly labile oxazoline from Aegle marmelos: the parent compound of aegeline and related amides
  作者：Shaheen Faizi、Fatima Farooqi、Sadia Zikr-Ur-Rehman、Aneela Naz、Fatima Noor、Farheen Ansari、Aqeel Ahmad、Shakeel Ahmed Khan

  DOI：10.1016/j.tet.2008.11.088

  日期：2009.1

  A rare alkaloid, shahidine (1), having an unstable oxazoline core has been isolated as a major constituent from the fresh leaves of Aegle marmelos. It is moisture-sensitive, and found to be the parent compound of aegeline and other amides, however. it is stable in dimethyl sulfoxide. Its structure was established by spectroscopic analysis. Biogenetically, oxazolines may be considered as the precursor of hydroxy amides and oxazoles found in plants. Shahidine (1) showed activity against a few Gram-positive bacteria. (C) 2008 Elsevier Ltd. All rights reserved.