2-(2,4-dimethoxyphenyl)-6,7-dihydro-5H-indeno[5,6-d]thiazole | 1446352-32-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-dimethoxyphenyl)-6,7-dihydro-5H-indeno[5,6-d]thiazole
• 英文别名: 2-(2,4-dimethoxyphenyl)-6,7-dihydro-5H-cyclopenta[f][1,3]benzothiazole
• CAS: 1446352-32-4
• 化学式: C₁₈H₁₇NO₂S
• 分子量: 311.404
• InChiKey: ZVQBPBVWWYZLOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2,4-dimethoxyphenyl)-6,7-dihydro-5H-indeno[5,6-d]thiazole 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 12.5h， 以58.7%的产率得到4-(6,7-dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol
  参考文献：
  名称：

  De novo tyrosinase inhibitor: 4-(6,7-Dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556)

  摘要：

  In this study, we have synthesized and studied de novo tyrosinase inhibitor, MHY1556, which showed significantly better efficacy than other pre-existing tyrosinase inhibitors in vitro experiments. The IC50 value of MHY1556 was 0.50 mu M which was significantly lower than that of kojic acid ( IC50 = 53.95 mu M), which is a well-known tyrosinase inhibitor and was used as a positive control in this study. We predicted the tertiary structure of tyrosinase, simulated the docking with compound MHY1556 and confirmed that the compound strongly interacts with mushroom tyrosinase residues. Substitutions with a hydroxy group at both R1 and R3 of the phenyl ring indicated that these groups play a major role in the high binding affinity to tyrosinase, especially through the hydrogen bonding interaction of the hydroxyl group at R1 with GLY281. In addition, MHY1556 showed concentration-dependent inhibitory effects in melanin content assay where B16F10 melanoma cells were treated with alpha-melanocyte stimulating hormone (alpha-MSH), and also there is no significant cytotoxicity of this compound in cell viability assay conducted in B16F10 melanoma cells. The tyrosinase activity assay results with MHY1556 also support its potent inhibitory effects. Therefore, our data strongly suggest MHY1556 suppresses the melanogenesis via a tyrosinase inhibitory effect. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.05.029
• 作为产物：
  描述：

  1-benzoyl-3-2,3-dihydro-1H-inden-5-ylthiourea 在 sodium metabisulfite 、 溴 、 potassium hydroxide 、 sodium hydroxide 作用下， 以 乙二醇甲醚 、 水 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 生成 2-(2,4-dimethoxyphenyl)-6,7-dihydro-5H-indeno[5,6-d]thiazole
  参考文献：
  名称：

  De novo tyrosinase inhibitor: 4-(6,7-Dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556)

  摘要：

  In this study, we have synthesized and studied de novo tyrosinase inhibitor, MHY1556, which showed significantly better efficacy than other pre-existing tyrosinase inhibitors in vitro experiments. The IC50 value of MHY1556 was 0.50 mu M which was significantly lower than that of kojic acid ( IC50 = 53.95 mu M), which is a well-known tyrosinase inhibitor and was used as a positive control in this study. We predicted the tertiary structure of tyrosinase, simulated the docking with compound MHY1556 and confirmed that the compound strongly interacts with mushroom tyrosinase residues. Substitutions with a hydroxy group at both R1 and R3 of the phenyl ring indicated that these groups play a major role in the high binding affinity to tyrosinase, especially through the hydrogen bonding interaction of the hydroxyl group at R1 with GLY281. In addition, MHY1556 showed concentration-dependent inhibitory effects in melanin content assay where B16F10 melanoma cells were treated with alpha-melanocyte stimulating hormone (alpha-MSH), and also there is no significant cytotoxicity of this compound in cell viability assay conducted in B16F10 melanoma cells. The tyrosinase activity assay results with MHY1556 also support its potent inhibitory effects. Therefore, our data strongly suggest MHY1556 suppresses the melanogenesis via a tyrosinase inhibitory effect. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.05.029