Ethyl 3-(3-bromo-4-hydroxyphenyl)-2-ethoxypropanoate | 544478-44-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Ethyl 3-(3-bromo-4-hydroxyphenyl)-2-ethoxypropanoate
• CAS: 544478-44-6
• 化学式: C₁₃H₁₇BrO₄
• 分子量: 317.18
• InChiKey: BIVRDEFSSCIOBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 3-(3-bromo-4-hydroxyphenyl)-2-ethoxypropanoate 在 sodium carbonate 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 42.0h， 生成 3-[3-Bromo-4-[2-(3-oxothieno[3,2-b][1,4]oxazin-4-yl)ethoxy]phenyl]-2-ethoxypropanoic acid
  参考文献：
  名称：

  Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents

  摘要：

  A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00976-9
• 作为产物：
  描述：

  4-苄氧基苯甲醛 在 palladium on activated charcoal N-溴代丁二酰亚胺(NBS) 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 四氯化碳 为溶剂， 60.0 ℃ 、413.68 kPa 条件下， 反应 3.0h， 生成 Ethyl 3-(3-bromo-4-hydroxyphenyl)-2-ethoxypropanoate
  参考文献：
  名称：

  Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents

  摘要：

  A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00976-9

文献信息

• Novel compounds, their preparation and use
  申请人：——

  公开号：US20030109579A1

  公开（公告）日：2003-06-12

  A novel class of dicarboxylic acid derivatives, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR).

  一种新型的二羧酸衍生物类，这些化合物作为药物组合物的用途，包括这些化合物的药物组合物以及使用这些化合物和组合物的治疗方法。这些化合物可能在治疗和/或预防由过氧化物酶体增殖物激活受体（PPAR）介导的疾病中有用。
• DICARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
  申请人：NOVO NORDISK A/S

  公开号：EP1438283A1

  公开（公告）日：2004-07-21
• US7220877B2
  申请人：——

  公开号：US7220877B2

  公开（公告）日：2007-05-22
• [EN] DICARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL USE<br/>[FR] DERIVES D'ACIDE DICARBOXYLIQUE, LEUR PREPARATION ET LEUR UTILISATION THERAPEUTIQUE
  申请人：NOVO NORDISK AS

  公开号：WO2003033453A1

  公开（公告）日：2003-04-24

  A novel class of dicarboxylic acid derivatives, the use of these compounds as phar-maceutical compositions, pharmaceutical compositions comprising the compounds and meth-ods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Prolifera-tor-Activated Receptors (PPAR).
• Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents
  作者：Saibal Kumar Das、K.Anantha Reddy、Chandrasekhar Abbineni、Javed Iqbal、J. Suresh、M. Premkumar、Ranjan Chakrabarti

  DOI：10.1016/s0960-894x(02)00976-9

  日期：2003.2

  A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.