(S)-methyl 6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoate | 675601-23-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-methyl 6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoate
• 英文别名: (S,2S,2'S)-N,N'-(3,3'-(2-(4-(4-(3-(3,5-diamino-6-chloropyrazin-2-carbonyl)guanidino)butyl)phenoxy)ethylazanediyl)bis(propane-3,1-diyl))bis(2-amino-6-((S)-2,6-diaminohexanamido)hexanamide)；Boc-Lys(1)-OMe.Boc-Lys(Boc)-(1)；methyl (2S)-6-[[(2S)-2,6-bis[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate
• CAS: 675601-23-7
• 化学式: C₂₈H₅₂N₄O₉
• 分子量: 588.742
• InChiKey: DNKJWGCTYKIIBY-PMACEKPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  41
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  170
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (S)-methyl 6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoate 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 (S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid
  参考文献：
  名称：

  DIPEPTIDE ACETYLENE CONJUGATES AND A METHOD FOR PHOTOCLEAVAGE OF DOUBLE STRAND DNA BY DIPEPTIDE ACETYLENE CONJUGATES

  摘要：

  提供了光反应性DNA切割共轭化合物，其中包含一个含有芳基炔基团的DNA切割部分和一个含有至少一个或两个氨基团的多功能pH调节DNA结合部分。

  公开号：

  US20120288940A1
• 作为产物：
  描述：

  (S)-2,6-二叔丁氧羰基氨基己酸 、 N-α-(tert-butoxycarbonyl)-L-lysine methyl ester 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到(S)-methyl 6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoate
  参考文献：
  名称：

  DIPEPTIDE ACETYLENE CONJUGATES AND A METHOD FOR PHOTOCLEAVAGE OF DOUBLE STRAND DNA BY DIPEPTIDE ACETYLENE CONJUGATES

  摘要：

  提供了光反应性DNA切割共轭化合物，其中包含一个含有芳基炔基团的DNA切割部分和一个含有至少一个或两个氨基团的多功能pH调节DNA结合部分。

  公开号：

  US20120288940A1

文献信息

• DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES
  申请人：PARION SCIENCES, INC.

  公开号：US20130324559A1

  公开（公告）日：2013-12-05

  Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.

  由以下公式代表的钠通道阻滞剂：在此处定义结构变量。 该发明还包括各种组合和使用这些创新性钠通道阻滞剂的治疗方法。
• DITHIOL MUCOLYTIC AGENTS
  申请人：Johnson Michael R.

  公开号：US20150056305A1

  公开（公告）日：2015-02-26

  Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.

  提供了二硫醚粘液溶解剂。这些剂增加了病人体内过多黏液或具有增加的粘弹性、黏着性或粘附性的黏液的液化。还提供了使用这些创新黏液溶解剂的各种治疗方法。
• Engineering pH-Gated Transitions for Selective and Efficient Double-Strand DNA Photocleavage in Hypoxic Tumors
  作者：Wang-Yong Yang、Saumya Roy、Boondaniwon Phrathep、Zach Rengert、Rachael Kenworthy、Diego A. R. Zorio、Igor V. Alabugin

  DOI：10.1021/jm2010282

  日期：2011.12.22

  We describe a family of hybrid compounds for the most efficient light-activated double-strand (ds) DNA cleavage known to date. This family represents the second generation of "switchable" molecular systems for pH-gated ds DNA-cleavage which combine a potent DNA-photocleaver and a pH-regulated part derived from a dipeptide. Design of the pH-switchable part utilizes amino groups of different basicity. Whereas the basic amino groups are protonated throughout the biologically relevant pH range, the pH-gating amines undergo protonation at the pH threshold which separates cancer and normal cells. Control over the reactivity and selectivity is achieved via transformation of the initial protonation state (a monocation or a dication) into a trication at the acidic pH. This change leads to an extraordinary increase in the efficiency of ds DNA cleavage leading to the ds:ss ratios comparable with the most efficient nonenzymatic ds DNA cleavers. Statistical analysis reveals that these high ds:ss ratios result from the combination of several factors: (a) true double-stranded cleavage, and (b) conversion of single-stranded (ss)-scission into ds cleavage. Considerable part of ds cleavage is also produced via the combination of ss cleavage events.
• US9346753B2
  申请人：——

  公开号：US9346753B2

  公开（公告）日：2016-05-24
• US9963427B2
  申请人：——

  公开号：US9963427B2

  公开（公告）日：2018-05-08