N-(4-phenyl)benzoyl sarcosine methyl ester | 1093641-49-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-phenyl)benzoyl sarcosine methyl ester
• 英文别名: [(Biphenyl-4-carbonyl)-methyl-amino]-acetic acid methyl ester；methyl 2-[methyl-(4-phenylbenzoyl)amino]acetate
• CAS: 1093641-49-6
• 化学式: C₁₇H₁₇NO₃
• 分子量: 283.327
• InChiKey: UHIYISZNJLNGDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  氢氧化锂 、 N-(4-phenyl)benzoyl sarcosine methyl ester 、 水 、 盐酸 以 Methanol tetrahydrofuran water 为溶剂， 反应 4.0h， 以to afford 250 mg (79.7% yield) of [(biphenyl-4-carbonyl)-methyl-amino]-acetic acid的产率得到[(Biphenyl-4-carbonyl)-methyl-amino]-acetic acid
  参考文献：
  名称：

  NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

  摘要：

  本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的吡啶二元衍生物。本发明还涉及制备该化合物的方法、含有该化合物的组合物以及使用该化合物进行治疗的方法。

  公开号：

  US20090221583A1
• 作为产物：
  描述：

  肌氨酸甲酯盐酸盐 、 对苯基苯甲醛 在 叔丁基过氧化氢 、 calcium carbonate 作用下， 以 水 为溶剂， 反应 16.0h， 以76%的产率得到N-(4-phenyl)benzoyl sarcosine methyl ester
  参考文献：
  名称：

  Tandem oxidative amidation of benzyl alcohols with amine hydrochloride salts catalysed by iron nitrate

  摘要：

  A tandem process for the oxidative amidation of benzyl alcohols with amine hydrochloride salts has been developed using inexpensive Fe(NO3)(3) as the catalyst, air and aqueous t-butyl hydroperoxide as oxidants. A wide range of benzamides have been synthesized under mild conditions. This greener amide formation method provides an economical and practical assess to benzamides from readily available and inexpensive starting materials. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.005

文献信息

• Piperazine derivatives as inhibitors of stearoyl-CoA desaturase
  申请人：Forest Laboratories Holdings Limited

  公开号：US07842696B2

  公开（公告）日：2010-11-30

  The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

  本发明涉及一种作为硬脂酰辅酶A脱饱和酶抑制剂的哌嗪衍生物。本发明还涉及制备这些化合物的方法，含有这些化合物的组合物，以及使用这些化合物的治疗方法。
• US7842696B2
  申请人：——

  公开号：US7842696B2

  公开（公告）日：2010-11-30
• [EN] NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE<br/>[FR] NOUVEAUX DÉRIVÉS DE PIPÉRAZINE EN TANT QU'INHIBITEURS DE STÉAROYL-COA DÉSATURASE
  申请人：FOREST LAB HOLDINGS LTD

  公开号：WO2008157844A1

  公开（公告）日：2008-12-24

  [EN] The present invention relates to piperazine derivatives that act as inhibitors of stearoyl- CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
  [FR] La présente invention concerne des dérivés de pipérazine qui agissent en tant qu'inhibiteurs de la stéaroyl-CoA désaturase. L'invention concerne également des procédés de préparation des composés, des compositions contenant les composés et des procédés de traitement utilisant les composés.
• Tandem oxidative amidation of benzyl alcohols with amine hydrochloride salts catalysed by iron nitrate
  作者：Subhash Chandra Ghosh、Joyce S.Y. Ngiam、Abdul M. Seayad、Dang Thanh Tuan、Charles W. Johannes、Anqi Chen

  DOI：10.1016/j.tetlet.2013.07.005

  日期：2013.9

  A tandem process for the oxidative amidation of benzyl alcohols with amine hydrochloride salts has been developed using inexpensive Fe(NO3)(3) as the catalyst, air and aqueous t-butyl hydroperoxide as oxidants. A wide range of benzamides have been synthesized under mild conditions. This greener amide formation method provides an economical and practical assess to benzamides from readily available and inexpensive starting materials. (C) 2013 Elsevier Ltd. All rights reserved.
• NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
  申请人：BISCHOFF Alexander

  公开号：US20090221583A1

  公开（公告）日：2009-09-03

  The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

  本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的吡啶二元衍生物。本发明还涉及制备该化合物的方法、含有该化合物的组合物以及使用该化合物进行治疗的方法。