2,6-Diethyl-N1-(2-imidazolidinylidene)-1,4-benzenediamine | 86861-20-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-Diethyl-N1-(2-imidazolidinylidene)-1,4-benzenediamine
• 英文别名: 1-N-(4,5-dihydro-1H-imidazol-2-yl)-2,6-diethylbenzene-1,4-diamine
• CAS: 86861-20-3
• 化学式: C₁₃H₂₀N₄
• 分子量: 232.329
• InChiKey: RRLPGZRCLDKQBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  62.4
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-Diethyl-N1-(2-imidazolidinylidene)-1,4-benzenediamine 生成 N-[4-(4,5-dihydro-1H-imidazol-2-ylamino)-3,5-diethylphenyl]acetamide
  参考文献：
  名称：

  YORK, B. M. ,, JR.

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二乙基苯胺 在 盐酸 、 水 、 硝酸 、 铁粉 、 溶剂黄146 、 sodium nitrite 、 三氯氧磷 作用下， 以 乙醇 、 水 为溶剂， 反应 9.5h， 生成 2,6-Diethyl-N1-(2-imidazolidinylidene)-1,4-benzenediamine
  参考文献：
  名称：

  A probe for octopamine receptors. Synthesis of 2-[(4-azido-2,6-diethylphenyl)imino]imidazolidine and its tritiated derivative, a potent reversible irreversible activator of octopamine-sensitive adenylate cyclase

  摘要：

  In order to develop an irreversible ligand for octopamine receptors, a highly potent azido-substituted 2-(phenyl-imino)imidazolidine (NC-5Z, 8) and its tritiated derivative (3H-NC-5Z, 11) have been designed and synthesized. Under reversible-binding conditions, NC-5Z is 50-100-fold more potent than octopamine in activating octopamine-sensitive adenylate cyclase in a variety of tissues. After photolysis, 3H-NC-5Z binds irreversibly to cell membranes, and this binding is reduced by preincubation with octopamine agonists and antagonists but not by norepinephrine, dopamine, serotonin, or histamine. NC-5Z should be useful both as a potent reversible octopamine agonist and as an affinity probe for characterizing and isolating octopamine-receptor proteins.

  DOI：

  10.1021/jm00128a022

文献信息

• Topical compostions for lowering intraocular pressure
  申请人：ALCON LABORATORIES, INC.

  公开号：EP0081924B1

  公开（公告）日：1986-02-19
• AZIDO-SUBSTITUTED OCTOPAMINE AGONISTS AND THE USE THEREOF TO CONTROL INVERTEBRATE PESTS
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP0484325A1

  公开（公告）日：1992-05-13
• EP0484325A4
  申请人：——

  公开号：EP0484325A4

  公开（公告）日：1992-06-24
• US4892871A
  申请人：——

  公开号：US4892871A

  公开（公告）日：1990-01-09
• [EN] AZIDO-SUBSTITUTED OCTOPAMINE AGONISTS AND THE USE THEREOF TO CONTROL INVERTEBRATE PESTS
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：WO1989009542A1

  公开（公告）日：1989-10-19

  (EN) The invention is directed to azido-substituted octopamine agonists and the radiolabeled derivatives thereof. The invention also relates to pest controlling compositions comprising the azido-substituted octopamine agonists of the invention. The invention also relates to methods of controlling invertebrate pests by bringing the pest into contact with an invertebrate pest-controlling composition of the invention and to an apparatus for controlling invertebrate pests utilizing the pest-controlling compositions of the invention. The pest-controlling compositions may be used alone or in conjunction with ultraviolet light. The invention also relates to methods for the isolation of octopamine receptor proteins utilizing the radiolabeled azido-substituted octopamine agonists of the invention.(FR) L'invention concerne des agonistes d'octopamine à substitution d'azido et leurs dérivés à marquage radioactif. l'invention concerne également des compositions de maîtrise de parasites, comprenant les agonistes d'octopamine à substitution d'azido de l'invention. Elle concerne aussi des procédés de maîtrise des parasites invertébrés consistant à amener les parasites en contact avec une desdites compositions de maîtrise de parasites invertébrés, ainsi qu'un appareil permettant de maîtriser les parasites invertébrés utilisant lesdites compositions de maîtrise de parasites. On peut utiliser les compositions de maîtrise de parasites seules ou conjointement avec la lumière ultraviolette. L'invention concerne en outre des procédés d'isolation de protéines réceptrices d'octopamine utilisant lesdits agonistes d'octopamine à substitution d'azido à marquage radioactif.