(S)-(2-溴乙基)环氧乙烷 | 61847-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 中文名称: (S)-(2-溴乙基)环氧乙烷
• 中文别名: S(-)-4-溴-1,2-环氧丁烷；(S)-4-溴-1,2-环氧基丁烷；(S)-(-)-4-溴-1,2-环氧丁烷
• 英文名称: (S)-(+)-4-bromo-1,2-epoxybutane
• 英文别名: (S)-2-(bromoethyl) oxirane；(S)-3,4-Epoxybutyl bromide；S(-)-4-bromo-1,2-epoxybutane；(S)-(-)-4-bromo-1,2-epoxybutane；(S)-(-)-(2-bromoethyl)oxirane；(2S)-2-(2-bromoethyl)oxirane；(S)-2-(2-Bromoethyl)oxirane
• CAS: 61847-07-2
• 化学式: C₄H₇BrO
• mdl: MFCD00042984
• 分子量: 151.003
• InChiKey: ZKODPGZNBMIZFX-BYPYZUCNSA-N

物化性质

• 沸点：
  80 °C50 mm Hg(lit.)
• 密度：
  1.521 g/mL at 20 °C(lit.)
• 闪点：
  59 °C
• 稳定性/保质期：
  在指定条件下稳定，远离氧化物。

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险等级：
  3.2
• 危险品标志：
  Xi
• 安全说明：
  S23,S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2910900090
• 包装等级：
  III
• 危险类别：
  3.2
• WGK Germany：
  3
• 危险品运输编号：
  UN 1993 3/PG 3
• 危险性防范说明：
  P210,P240,P241,P242,P243,P261,P264,P270,P271,P280,P302+P352,P303+P361+P353,P304+P340,P305+P351+P338,P310,P330,P332+P313,P362,P370+P378,P403+P233,P403+P235,P405,P501
• 危险性描述：
  H225,H302,H315,H318,H335

反应信息

• 作为反应物：
  描述：

  (S)-(2-溴乙基)环氧乙烷 在 sodium sulfide nonahydrate 作用下， 以 乙腈 为溶剂， 反应 14.0h， 以89%的产率得到3-羟基四氢呋喃
  参考文献：
  名称：

  Synthesis of a variety of optically active hydroxylated heterocyclic compounds using epoxide hydrolase technology

  摘要：

  Novel epoxide hydrolases in Yarrowia lipolytica have been shown to hydrolyse a variety of functionalised epoxides with good to excellent stereoselectivity and at high volumetric productivities. Individual biotransformation products have been converted into optically active (R)-(tetrahydrofun-2-yl)methanol (6), (S)-N-benzyl-3-hydroxypyrrolidine (7), (S)-3-hydroxytetrahydrothiophene (8), (S)-N-benzyl-3-acetoxypiperidine (10), (S)-3-hydroxytetrahydrofuran (16) and (R)-[(S)-N-benzylpyrrolidin-2-yl](phenyl)-methanol (20). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.097
• 作为产物：
  描述：

  4-溴-1,2-环氧丁烷 在 Yarrowia lipolytica epoxide hydrolase (Oxy-9) 、 水 作用下， 反应 1.5h， 以26%的产率得到(S)-(2-溴乙基)环氧乙烷
  参考文献：
  名称：

  Synthesis of a variety of optically active hydroxylated heterocyclic compounds using epoxide hydrolase technology

  摘要：

  Novel epoxide hydrolases in Yarrowia lipolytica have been shown to hydrolyse a variety of functionalised epoxides with good to excellent stereoselectivity and at high volumetric productivities. Individual biotransformation products have been converted into optically active (R)-(tetrahydrofun-2-yl)methanol (6), (S)-N-benzyl-3-hydroxypyrrolidine (7), (S)-3-hydroxytetrahydrothiophene (8), (S)-N-benzyl-3-acetoxypiperidine (10), (S)-3-hydroxytetrahydrofuran (16) and (R)-[(S)-N-benzylpyrrolidin-2-yl](phenyl)-methanol (20). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.097

文献信息

• [EN] TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS<br/>[FR] COMPOSÉS AZOTÉS TRICYCLIQUES ET LEUR UTILISATION COMME AGENTS ANTIBACTÉRIENS
  申请人：GLAXO GROUP LTD

  公开号：WO2009087153A1

  公开（公告）日：2009-07-16

  Tricyclic nitrogen containing compounds and their use as antibacterials.

  三环氮含有化合物及其作为抗菌剂的用途。
• Diastereoselective Synthesis of Cyclic Ethers by Radical Cyclization at β-Position of β-Alkoxyacrylates
  作者：Yoko Yuasa、Wataru Sato、Shiroshi Shibuya

  DOI：10.1080/00397919708003328

  日期：1997.2

  Abstract Regioselective carbon-carbon bond formation by radical reaction at the β-position of β-alkoxyacrylate was applied to a synthesis of 2,5-disubstituted tetrahydrofuran, 2,6-disubstituted tetrahydropyran, 2,7-disubstituted oxepane derivatives.

  摘要 将β-烷氧基丙烯酸酯β-位自由基反应形成区域选择性碳-碳键用于合成2,5-二取代四氢呋喃、2,6-二取代四氢吡喃、2,7-二取代氧杂环庚烷衍生物。
• METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS
  申请人：Papamichelakis Maria

  公开号：US20090156826A1

  公开（公告）日：2009-06-18

  The present invention is directed to processes for the preparation of hydroxy-substituted aryl sulfamide derivatives of the formula I or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, which are monoamine reuptake inhibitors wherein the constituent variables are as defined herein.

  本发明涉及制备式I的羟基取代芳基磺酰胺衍生物或其药学上可接受的盐、立体异构体或互变异构体的过程，其中所述衍生物是单胺再摄取抑制剂，其组成变量如本文所定义。
• SUBSTITUTED BENZOTHIADIAZINEDIOXIDE DERIVATIVES AND METHODS OF THEIR USE
  申请人：Goldberg Joel Adam

  公开号：US20080161295A1

  公开（公告）日：2008-07-03

  The present invention is directed to substituted benzothiadiazinedioxide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

  本发明涉及公式I的取代苯并噻二氧化物衍生物，或其药学上可接受的盐、立体异构体或互变异构体，这些衍生物是单胺重摄取抑制剂，包含这些衍生物的组合物，以及它们用于预防和治疗疾病或疾病的方法，包括但不限于血管运动症状、性功能障碍、胃肠障碍和泌尿生殖障碍、抑郁症、内源性行为障碍、认知障碍、糖尿病神经病变、疼痛和其他疾病或疾病。
• TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS
  申请人：Brown Pamela

  公开号：US20110009394A1

  公开（公告）日：2011-01-13

  Tricyclic nitrogen containing compounds and their use as antibacterials.

  三环氮含有化合物及其作为抗菌剂的使用。