Dimethyl 2-[(2-hydroxyphenyl)-[(2-hydroxyphenyl)methylideneamino]methyl]propanedioate | 77008-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Dimethyl 2-[(2-hydroxyphenyl)-[(2-hydroxyphenyl)methylideneamino]methyl]propanedioate
• CAS: 77008-37-8
• 化学式: C₁₉H₁₉NO₆
• 分子量: 357.363
• InChiKey: YNEVOEUFIZHSFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  甲醇 、 Dimethyl 2-[(2-hydroxyphenyl)-[(2-hydroxyphenyl)methylideneamino]methyl]propanedioate 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 0.5h， 以91%的产率得到12H,14H-[1,3,2]benzoxazaborinino[2,3-b][1,3,2]benzoxazaborinine*methanol
  参考文献：
  名称：

  Preparation of cyclic boramides from salicylaldehydes, ammonium acetate and sodium borohydride

  摘要：

  Borohydride reduction of salicylaldehyde imines yields surprisingly a cyclic boramide. This is a fairly stable compound, and X-ray analysis shows it has a tetrahedral boron atom. Mechanistic studies show a reaction pathway through an oxazaborinane intermediate. The reaction also works with halogen substituted salicylaldehydes and for the preparation of non-symmetrical boramides. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.09.053
• 作为产物：
  描述：

  水杨醛 、 丙二酸二甲酯 在 ammonium acetate 作用下， 以80%的产率得到Dimethyl 2-[(2-hydroxyphenyl)-[(2-hydroxyphenyl)methylideneamino]methyl]propanedioate
  参考文献：
  名称：

  Preparation of cyclic boramides from salicylaldehydes, ammonium acetate and sodium borohydride

  摘要：

  Borohydride reduction of salicylaldehyde imines yields surprisingly a cyclic boramide. This is a fairly stable compound, and X-ray analysis shows it has a tetrahedral boron atom. Mechanistic studies show a reaction pathway through an oxazaborinane intermediate. The reaction also works with halogen substituted salicylaldehydes and for the preparation of non-symmetrical boramides. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.09.053

文献信息

• A Facile Synthesis of Perhydropyrimidines through the Michael Addition of Some Active Methylene Compounds to<i>N</i>,<i>N</i>′-Dibenzylidenephenylmethanediamines and Some Related Reactions
  作者：T. Takajo、S. Kambe

  DOI：10.1055/s-1980-29227

  日期：——