tert-butyl[(1S)-3-amino-1-(hydroxymethyl)propyl]carbamate | 849815-38-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl[(1S)-3-amino-1-(hydroxymethyl)propyl]carbamate
• 英文别名: tert-butyl N-[(2S)-4-amino-1-hydroxybutan-2-yl]carbamate
• CAS: 849815-38-9
• 化学式: C₉H₂₀N₂O₃
• 分子量: 204.269
• InChiKey: SXQVAAFPVARXPS-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  84.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl[(1S)-3-amino-1-(hydroxymethyl)propyl]carbamate 在 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 tert-butyl N-[(2S)-1-hydroxy-4-[methyl-(2,2,2-trifluoroacetyl)amino]butan-2-yl]carbamate
  参考文献：
  名称：

  Exploration of the P1 SAR of aldehyde cathepsin K inhibitors

  摘要：

  The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.

  DOI：

  10.1016/j.bmcl.2003.09.088
• 作为产物：
  描述：

  (S)-2-(Boc-氨基)-4-(Fmoc-氨基)丁酸 在 sodium tetrahydroborate 、 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 tert-butyl[(1S)-3-amino-1-(hydroxymethyl)propyl]carbamate
  参考文献：
  名称：

  Exploration of the P1 SAR of aldehyde cathepsin K inhibitors

  摘要：

  The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.

  DOI：

  10.1016/j.bmcl.2003.09.088

文献信息

• METHODS FOR INHIBITING DRUG DEGRADATION
  申请人：SEQUOIA PHARMACEUTICALS, INC.

  公开号：US20150284352A1

  公开（公告）日：2015-10-08

  Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

  提供了一种抑制细胞色素P450酶的方法，可用于改善疾病治疗，防止药物或其他分子被细胞色素P450降解。提供了可以充当增强剂的药物组合物，以改善药物的药代动力学，增加生物利用度，并增强那些在体内被细胞色素P450酶降解的药物的治疗效果。
• [EN] HIV PROTEASE INHIBITOR AND CYTOCHROME P450 INHIBITOR COMBINATIONS<br/>[FR] INHIBITEUR DE LA PROTÉASE DU VIH ET INHIBITEUR DU CYTOCHROME P450 COMBINÉS
  申请人：SEQUOIA PHARMACEUTICALS INC

  公开号：WO2009105782A1

  公开（公告）日：2009-08-27

  Compositions and methods of treating viral infections are provided. More particularly, compositions including a combination of protease inhibitors and cytochrome p450 enzyme inhibitors are provided. Methods of using the compositions for treatment of diseases or disorders caused by a virus such as HIV infections are also provided.

  提供治疗病毒感染的组合物和方法。更具体地，提供了包括蛋白酶抑制剂和细胞色素P450酶抑制剂的组合物。还提供了使用这些组合物治疗由病毒（如HIV感染）引起的疾病或失调的方法。
• ANTIBACTERIAL AMIDE MACROCYCLES IV
  申请人：Endermann Rainer

  公开号：US20080076745A1

  公开（公告）日：2008-03-27

  The invention relates to antibacterial amide macrocycles and processes for their preparation, their use for the treatment and/or prophylaxis of diseases and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially bacterial infections.

  该发明涉及抗菌酰胺大环化合物及其制备过程，其用于治疗和/或预防疾病以及用于制造治疗和/或预防疾病，特别是细菌感染的药物。
• Antibacterial amide macrocycles IV
  申请人：AiCuris GmbH & Co. KG

  公开号：US07446102B2

  公开（公告）日：2008-11-04

  The invention relates to antibacterial amide macrocycles and processes for their preparation, their use for the treatment and/or prophylaxis of diseases and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially bacterial infections.

  本发明涉及抗菌酰胺大环化合物及其制备方法，以及它们用于治疗和/或预防疾病的用途，以及用于制造治疗和/或预防疾病，特别是细菌感染的药物的用途。
• WO2008/22345
  申请人：——

  公开号：——

  公开（公告）日：——