2-[2-[(E)-2-cyclohexylethenyl]phenoxy]-N,N-diethylethanamine | 63623-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[2-[(E)-2-cyclohexylethenyl]phenoxy]-N,N-diethylethanamine
• CAS: 63623-99-4
• 化学式: C₂₀H₃₁NO
• 分子量: 301.472
• InChiKey: JTAPDFKORRCURI-CCEZHUSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-[2-(二乙胺基)乙氧基]苯甲醛 在 氯化亚砜 作用下， 生成 2-[2-[(E)-2-cyclohexylethenyl]phenoxy]-N,N-diethylethanamine
  参考文献：
  名称：

  Compounds with gastric antisecretory activity. 1. Phenoxyalkylamines

  摘要：

  A series of 0-alkylphenoxyalkylamines, derived from classical H1 antagonists, has been found to inhibit histamine-induced gastric acid secretion. The most potent compound was trans-1-[2[2-[2-(1-adamantyl)vinyl] phenoxy] ethyl]pyrrolidine (54). The 0-acylphenol 23 required for the preparation of 54 was obtained by the novel reaction of 1-bromoadamantane (21) with 4-hydroxycoumarin (20) using diethyl phosphonate as solvent. The product 22 was then hydrolyzed under basic conditions to give 23 in high yield. 54 was not an H2 antagonist and its mode of action remains unknown. The compound had no significant anticholinergic, antiinflammatory, anticonvulsant, sedative, or H1-antihistaminic activity.

  DOI：

  10.1021/jm00220a018

文献信息

• US3910896A
  申请人：——

  公开号：US3910896A

  公开（公告）日：1975-10-07
• Compounds with gastric antisecretory activity. 1. Phenoxyalkylamines
  作者：Peter E. Cross、Roger P. Dickinson、John E. G. Kemp、Peter R. Leeming、Laurence G. Pullman

  DOI：10.1021/jm00220a018

  日期：1977.10

  A series of 0-alkylphenoxyalkylamines, derived from classical H1 antagonists, has been found to inhibit histamine-induced gastric acid secretion. The most potent compound was trans-1-[2[2-[2-(1-adamantyl)vinyl] phenoxy] ethyl]pyrrolidine (54). The 0-acylphenol 23 required for the preparation of 54 was obtained by the novel reaction of 1-bromoadamantane (21) with 4-hydroxycoumarin (20) using diethyl phosphonate as solvent. The product 22 was then hydrolyzed under basic conditions to give 23 in high yield. 54 was not an H2 antagonist and its mode of action remains unknown. The compound had no significant anticholinergic, antiinflammatory, anticonvulsant, sedative, or H1-antihistaminic activity.