7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylic acid | 131448-05-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylic acid
• 英文别名: 7-Methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylic acid；7-methyl-2,4-dioxo-3-phenyl-1H-pyrido[2,3-d]pyrimidine-5-carboxylic acid
• CAS: 131448-05-0
• 化学式: C₁₅H₁₁N₃O₄
• 分子量: 297.27
• InChiKey: ZZCXZVJFFZXQRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  99.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylic acid 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 7.0h， 生成 7-Methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylic acid chloride
  参考文献：
  名称：

  Investigations on the synthesis and pharmacological properties of amides of 7-methyl-3-phenyl-1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-2,4-dioxo-1,2,3,4-tetra-hydropyrido[2,3-d]pyrimidine-5-carboxylic acid

  摘要：

  Synthesis of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2, 3,4-tetrahydropyrido[2, 3-d]pyrimidine-5-carboxylic acid (6-10) and their 1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl] derivatives (11-15) are described. Some of them displayed strong analgesic activity. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00101-9
• 作为产物：
  描述：

  ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 反应 6.0h， 生成 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylic acid
  参考文献：
  名称：

  Investigations on the synthesis and pharmacological properties of amides of 7-methyl-3-phenyl-1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-2,4-dioxo-1,2,3,4-tetra-hydropyrido[2,3-d]pyrimidine-5-carboxylic acid

  摘要：

  Synthesis of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2, 3,4-tetrahydropyrido[2, 3-d]pyrimidine-5-carboxylic acid (6-10) and their 1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl] derivatives (11-15) are described. Some of them displayed strong analgesic activity. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00101-9

文献信息

• Sladowska; Bartoszko-Malik; Zawisza, Il Farmaco, 1990, vol. 45, # 1, p. 111 - 121
  作者：Sladowska、Bartoszko-Malik、Zawisza

  DOI：——

  日期：——
• Sladowska; Bartoszko-Malik; Zawisza, Il Farmaco, 1990, vol. 45, # 1, p. 101 - 110
  作者：Sladowska、Bartoszko-Malik、Zawisza

  DOI：——

  日期：——
• SLADOWSKA, H.;BARTOSZKO-MALIK, A.;ZAWISZA, T., FARMACO, 45,(1990) N, C. 101-110
  作者：SLADOWSKA, H.、BARTOSZKO-MALIK, A.、ZAWISZA, T.

  DOI：——

  日期：——
• SLADOWSKA, H.;BARTOSZKO-MALIK, A.;ZAWISZA, T., FARMACO, 45,(1990) N, C. 111-121
  作者：SLADOWSKA, H.、BARTOSZKO-MALIK, A.、ZAWISZA, T.

  DOI：——

  日期：——
• Investigations on the synthesis and pharmacological properties of amides of 7-methyl-3-phenyl-1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-2,4-dioxo-1,2,3,4-tetra-hydropyrido[2,3-d]pyrimidine-5-carboxylic acid
  作者：Helena Śladowska、Maria Sieklucka-Dziuba、Grażyna Rajtar、Mirosław Sadowski、Zdzisław Kleinrok

  DOI：10.1016/s0014-827x(99)00101-9

  日期：1999.11

  Synthesis of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2, 3,4-tetrahydropyrido[2, 3-d]pyrimidine-5-carboxylic acid (6-10) and their 1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl] derivatives (11-15) are described. Some of them displayed strong analgesic activity. (C) 1999 Elsevier Science S.A. All rights reserved.