7-methyl-5-(morpholine-4-carbonyl)-3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione | 259110-74-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 7-methyl-5-(morpholine-4-carbonyl)-3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione
• CAS: 259110-74-2
• 化学式: C₁₉H₁₈N₄O₄
• 分子量: 366.376
• InChiKey: XVTKMFCKNOBPFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  91.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[4-苯基哌嗪基]-2-羟丙基氯 、 7-methyl-5-(morpholine-4-carbonyl)-3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione 在 potassium ethoxide 作用下， 以 乙醇 为溶剂， 以60%的产率得到1-[2-Hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-7-methyl-5-(morpholine-4-carbonyl)-3-phenylpyrido[2,3-d]pyrimidine-2,4-dione
  参考文献：
  名称：

  Investigations on the synthesis and pharmacological properties of amides of 7-methyl-3-phenyl-1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-2,4-dioxo-1,2,3,4-tetra-hydropyrido[2,3-d]pyrimidine-5-carboxylic acid

  摘要：

  Synthesis of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2, 3,4-tetrahydropyrido[2, 3-d]pyrimidine-5-carboxylic acid (6-10) and their 1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl] derivatives (11-15) are described. Some of them displayed strong analgesic activity. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00101-9
• 作为产物：
  描述：

  ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate 在 盐酸 、 氯化亚砜 作用下， 以 溶剂黄146 、 苯 为溶剂， 反应 18.0h， 生成 7-methyl-5-(morpholine-4-carbonyl)-3-phenyl-1H-pyrido[2,3-d]pyrimidine-2,4-dione
  参考文献：
  名称：

  Investigations on the synthesis and pharmacological properties of amides of 7-methyl-3-phenyl-1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-2,4-dioxo-1,2,3,4-tetra-hydropyrido[2,3-d]pyrimidine-5-carboxylic acid

  摘要：

  Synthesis of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2, 3,4-tetrahydropyrido[2, 3-d]pyrimidine-5-carboxylic acid (6-10) and their 1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl] derivatives (11-15) are described. Some of them displayed strong analgesic activity. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00101-9