1-methyl-1,2-dihydrobenzoic acid | 32917-40-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-methyl-1,2-dihydrobenzoic acid
• 英文别名: 1-methyl-2,4-cyclohexadiencarbonsaeure；1-Methyl-3,5-cyclohexadiencarbonsaeure；1-Methylcyclohexa-2,4-diene-1-carboxylic acid
• CAS: 32917-40-1
• 化学式: C₈H₁₀O₂
• mdl: MFCD19228789
• 分子量: 138.166
• InChiKey: UXUYPXITXYMYLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methyl-1,2-dihydrobenzoic acid 在 palladium on activated charcoal 氢气 作用下， 生成 1-甲基环己烷羧酸
  参考文献：
  名称：

  Homo-Favorskii rearrangement

  摘要：

  DOI：

  10.1021/ja00742a020
• 作为产物：
  描述：

  1-methylcyclohexa-2,5-diene-1-carboxylic acid 在 氢氧化钾 作用下， 以97%的产率得到1-methyl-1,2-dihydrobenzoic acid
  参考文献：
  名称：

  Kuck, Dietmar; Schneider, Jens; Gruetzmacher, Hans-Friedrich, Journal of the Chemical Society. Perkin transactions II, 1985, p. 689 - 696

  摘要：

  DOI：

文献信息

• PHARMACEUTICAL COMPOSITION FOR TREATING AGING-ASSOCIATED DISEASES, CONTAINING PROGERIN EXPRESSION INHIBITOR AS ACTIVE INGREDIENT, AND SCREENING METHOD OF SAID PROGERIN EXPRESSION INHIBITOR
  申请人：Park Bum Joon

  公开号：US20140039010A1

  公开（公告）日：2014-02-06

  Disclosed are a method for treating an aging-related disease and a method for screening a therapeutic agent for an aging-related disease. The method for treating an aging-related disease includes administering to a subject a progerin expression inhibitor as an active ingredient. The method for screening a therapeutic agent for an aging-related disease includes selecting a candidate drug inhibitory of progerin expression.

  披露了一种治疗与衰老相关疾病的方法和一种筛选与衰老相关疾病治疗剂的方法。治疗与衰老相关疾病的方法包括向受试者施用一种蛋白质表达抑制剂作为活性成分。筛选与衰老相关疾病治疗剂的方法包括选择一种能抑制蛋白质表达的候选药物。
• Unkatalysierte sigmatrope 1,5-Wanderung von Acylgruppen bei der Thermolyse von 5-Acyl-5-methyl-1,3-cyclohexadienen
  作者：Peter Schiess、Rolf Dinkel、Peter Fünfschilling

  DOI：10.1002/hlca.19810640318

  日期：1981.4.29

  Uncatalyzed Sigmatropic 1,5-Shift of Acyl Groups in the Thermolysis of 5-Acyl-5-methyl-1,3-cyclohexadienes

  5-催化-5-甲基-1,3-环己二烯的热解中未催化的正向性1,5-酰基转移
• MULTICOMPONENT CRYSTALS COMPRISING DASATINIB AND SELECTED CO-CRYSTAL FORMERS
  申请人：BASF SE

  公开号：US20150133463A1

  公开（公告）日：2015-05-14

  Provided are a multicomponent crystalline system (co-crystal), use thereof, as well as a process for obtaining the same. The said multicomponent crystalline system (co-crystal) comprises Dasatinib and a second compound selected from methyM-hydrobenzoate, nicotinamide, ethyl gallate, methyl gallate, propyl gallate, ethyl maltol, vanillin, menthol, or (1R,2S,5R)-(−)-menthol.

  提供了一个多组分晶体系统（共晶体），以及其使用方法，以及获取该系统的过程。所述的多组分晶体系统（共晶体）包括达他西韦和从甲基对羟基苯甲酸酯、烟酰胺、乙基没食子酸酯、甲基没食子酸酯、丙基没食子酸酯、乙基麦芽酚、香草醛、薄荷脑或（1R,2S,5R）-（-）-薄荷脑中选择的第二化合物。
• ULTRAVIOLET ABSORBER, COMPOSITION FOR FORMING A RESIST UNDER LAYER FILM, AND PATTERNING PROCESS
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20160053087A1

  公开（公告）日：2016-02-25

  The present invention provides an ultraviolet absorber containing a compound represented by the formula (A-1), wherein R represents a methyl group, an ethyl group, a propyl group, or an allyl group, and R 1 , R 2 , R 3 , and R 4 may be the same or different, and each represent a hydrogen atom, a benzoyl group, a toluoyl group, a naphthoyl group, or an anthranoyl group. By adding the ultraviolet absorber to a composition for forming a resist under layer film, reflection can be suppressed particularly in lithography process by an ultraviolet laser, and a pattern profile can be improved without adverse effects on dry etching mask properties and adhesiveness to a resist pattern.

  本发明提供了一种含有式（A-1）所代表的化合物的紫外线吸收剂，其中R代表甲基基团、乙基基团、丙基基团或烯丙基基团，而R1、R2、R3和R4可以相同也可以不同，每个代表氢原子、苯甲酰基、甲苯酰基、萘甲酰基或蒽甲酰基。通过将紫外线吸收剂添加到用于形成抗蚀底层膜的组合物中，可以在紫外线激光的光刻过程中特别抑制反射，并且可以改善图案轮廓而不会对干法刻蚀掩模特性和对抗蚀图案的附着性产生不良影响。
• 1-substituted-3-acylpyrrole derivatives, process for their preparation and platelet aggregation inhibiting agents containing them
  申请人：TEIJIN LIMITED

  公开号：EP0002392A2

  公开（公告）日：1979-06-13

  The invention provides 1-substituted-3-acylpyrroles of the formula:- wherein is an optionaliy substituted phenyl group, a cycloalkyl or cycloalkenyl group. branched alkyl group, or optionally substituted heterocyclic group, R, is hydrogen or an alkyl group and R2, R3 and R4, are such that the substituent linked to the N-atom in the 1-position contains an alcoholic hydroxyl proup. an ether group, a thioether group or a functional group derived from oxidation of these groups linked to the N-atorn through a chain of two carbon atoms. The compounds of the invention, unlike known 3-acyl-1- substituted pyrrole derivatives, have high platelet aggregation inhibiting activities and low antiinflammatory activities. They may be made by acylating a 1-substituted pyrrole in the 3-position by reaction with an anhydride or halide of a carboxylic acid of the formula COOH, in the presence of an acid catalyst, and if desired subjecting the products to oxidation, hydrolysis, amidation or acetal-forming reaction.

  本发明提供了式中的 1-取代-3-酰基吡咯：- 1-取代-3-酰基吡咯 其中，R2、R3 和 R4 是任选取代的苯基、环烷基或环烯基、支链烷基或任选取代的杂环基团；R 是氢或烷基；R2、R3 和 R4 是这样的取代基：与 1 位 N 原子相连的取代基含有醇羟基、醚基、硫醚基或由这些基团通过两个碳原子链与 N 原子相连的氧化衍生的官能团。 与已知的 3-酰基-1-取代的吡咯衍生物不同，本发明的化合物具有较高的血小板聚集抑制活性和较低的抗炎活性。 本发明化合物的制备方法是：在酸催化剂存在下，通过与式 COOH 的羧酸的酸酐或卤化物反应，使 1-取代的吡咯在 3 位上酰化，并根据需要使产物进行氧化、水解、酰胺化或缩醛生成反应。