3-(Dimethylamino)-1-[4-(2-methylpropyl)phenyl]prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(Dimethylamino)-1-[4-(2-methylpropyl)phenyl]prop-2-en-1-one
• 化学式: C₁₅H₂₁NO
• 分子量: 231.338
• InChiKey: VVRMTQLORDIEHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(Dimethylamino)-1-[4-(2-methylpropyl)phenyl]prop-2-en-1-one 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以85 mg的产率得到1-(4-isobutylphenyl)propan-1-ol
  参考文献：
  名称：

  DMF Dimethyl Acetal as Carbon Source for α-Methylation of Ketones: A Hydrogenation–Hydrogenolysis Strategy of Enaminones

  摘要：

  A novel heterogeneous catalytic hydrogenation hydrogenolysis strategy has been developed for the alpha-methylation of ketones via enaminones using DMF dimethyl acetal as carbon source. This strategy provides a very convenient route to alpha-methylated ketones using a variety of ketones without any base or oxidant.

  DOI：

  10.1021/acs.joc.5b00084
• 作为产物：
  描述：

  4-异丁基苯乙酮 、 N,N-二甲基甲酰胺 以 N,N-二甲基乙酰胺 为溶剂， 反应 24.0h， 生成 3-(Dimethylamino)-1-[4-(2-methylpropyl)phenyl]prop-2-en-1-one
  参考文献：
  名称：

  DMF Dimethyl Acetal as Carbon Source for α-Methylation of Ketones: A Hydrogenation–Hydrogenolysis Strategy of Enaminones

  摘要：

  A novel heterogeneous catalytic hydrogenation hydrogenolysis strategy has been developed for the alpha-methylation of ketones via enaminones using DMF dimethyl acetal as carbon source. This strategy provides a very convenient route to alpha-methylated ketones using a variety of ketones without any base or oxidant.

  DOI：

  10.1021/acs.joc.5b00084

文献信息

• Enaminone-directed ruthenium(<scp>ii</scp>)-catalyzed C–H activation and annulation of arenes with diazonaphthoquinones for polycyclic benzocoumarins
  作者：Sudeshna Mondal、Chandan Kumar Giri、Mahiuddin Baidya

  DOI：10.1039/d3cc03999d

  日期：——

  coordinating enaminone functionality has been leveraged for a C–H bond activation strategy under ruthenium catalysis and employed in the regioselective annulative coupling of arenes with diazonaphthoquinones, offering polycyclic benzocoumarins in very high yields. The enaminone motif plays a dual role and the protocol operates through a Ru(II)/Ru(IV) catalytic pathway which is amenable to the diversification

  弱配位烯胺酮官能团已被用于钌催化下的C-H键活化策略，并用于芳烃与重氮萘醌的区域选择性环偶联，以非常高的产率提供多环苯并香豆素。烯胺酮基序发挥双重作用，该方案通过 Ru( II )/Ru( IV ) 催化途径进行操作，该途径适合各种药效团偶联底物的多样化。
• DMF Dimethyl Acetal as Carbon Source for α-Methylation of Ketones: A Hydrogenation–Hydrogenolysis Strategy of Enaminones
  作者：Ashwini Borah、Limi Goswami、Kashmiri Neog、Pranjal Gogoi

  DOI：10.1021/acs.joc.5b00084

  日期：2015.5.1

  A novel heterogeneous catalytic hydrogenation hydrogenolysis strategy has been developed for the alpha-methylation of ketones via enaminones using DMF dimethyl acetal as carbon source. This strategy provides a very convenient route to alpha-methylated ketones using a variety of ketones without any base or oxidant.