4-氧代-4-(4-吡啶基)丁酸 | 5693-75-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 中文名称: 4-氧代-4-(4-吡啶基)丁酸
• 英文名称: 4-oxo-4-(4-pyridyl)butanoic acid
• 英文别名: 4-oxo-4-pyridin-4-yl-butyric acid；4-Oxo-4-(pyridin-4-yl)butanoic acid；4-oxo-4-pyridin-4-ylbutanoic acid
• CAS: 5693-75-4
• 化学式: C₉H₉NO₃
• mdl: MFCD01320178
• 分子量: 179.175
• InChiKey: QHBYZGQLPMSIFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-氧代-4-(4-吡啶基)丁酸 生成 Dihydro-5-pyrid-4-yl-2(3H)-furanon
  参考文献：
  名称：

  γ-吡啶基-和γ-喹啉基-丁内酯作为潜在的驱虫剂

  摘要：

  一些 γ-吡啶基-和 γ-喹啉基-丁内酯被合成为潜在的抗蠕虫药，并针对 tubifex 蠕虫进行了临时测试。

  DOI：

  10.1002/ardp.19743070907
• 作为产物：
  描述：

  diethyl 4-pyridylcarbonylsuccinate 在 phosphate buffer 作用下， 反应 240.0h， 生成 4-氧代-4-(4-吡啶基)丁酸
  参考文献：
  名称：

  化学和酵母催化的非对映异构体乙基γ-苯基和γ-（n-吡啶基）对羟基苯甲酸酯的合成

  摘要：

  γ-苯基和γ-（n-吡啶基）对羟基甲酸酯的合成是通过化学还原它们各自的酮二酯前体，然后环化所得的羟基二酯中间体而完成的。分离由此获得的顺式和反式内酯，并分别用HLAP进行酶水解。所述CIS -lactonic酯具有对映体过量范围从94％至99％，而对于反式-异构体的ee值介于真实从80％至93％。将相同的酮二酸酯前体用一系列酵母进行还原。反式的绝对配置通过对其氢溴酸盐的X射线分析确定了-（-）-2-吡啶基对圆锥体酸，而其他内酯的绝对构型则通过分析其各自的CD曲线来确定。

  DOI：

  10.1016/j.tetasy.2008.08.011

文献信息

• Substituted Tetrahydropyrrolo[2,1-<i>b</i>]oxazol-5(6<i>H</i>)-ones and Tetrahydropyrrolo[2,1-<i>b</i>]thiazol-5(6<i>H</i>)-ones as Hypoglycemic Agents
  作者：Thomas D. Aicher、Bork Balkan、Philip A. Bell、Leonard J. Brand、S. H. Cheon、Rhonda O. Deems、Jay B. Fell、William S. Fillers、James D. Fraser、Jiaping Gao、Douglas C. Knorr、Gerald G. Kahle、Christina L. Leone、Jeffrey Nadelson、Ronald Simpson、Howard C. Smith

  DOI：10.1021/jm9803121

  日期：1998.11.1

  A series of substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-one and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids. A pharmacological model based on the results obtained with these compounds led to the synthesis and evaluation of a series of isoxazoles and other monocyclic compounds. These were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. The in vivo hypoglycemic efficacy and potency of these compounds were evaluated in a model of type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus), the ob/ob mouse. 25a(2S) (SDZ PGU 693) was selected for further pharmacological studies.
• LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：Chi Mei Corporation

  公开号：US20170152443A1

  公开（公告）日：2017-06-01

  A liquid crystal alignment agent allowing formation of an LCD element having good reliability and less residual image, a liquid crystal alignment film, and an LCD element having the liquid crystal alignment film are shown. The liquid crystal alignment agent includes a polymer (A), a photosensitive polysiloxane (B), and a solvent (C). The polymer (A) is obtained by reacting a mixture that includes a tetracarboxylic dianhydride component (a-1) and a diamine component (a-2). The photosensitive polysiloxane (B) is obtained by reacting a polysiloxane (b-1) having an epoxy group with a cinnamic acid derivative (b-2) and an aromatic heterocyclic derivative (b-3) containing nitride, oxide or sulfide.
• US4304777A
  申请人：——

  公开号：US4304777A

  公开（公告）日：1981-12-08
• US4305943A
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  公开（公告）日：1981-12-15
• US4298609A
  申请人：——

  公开号：US4298609A

  公开（公告）日：1981-11-03