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2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]-N-(4-methyl-2-oxochromen-7-yl)acetamide | 1130160-92-7

中文名称
——
中文别名
——
英文名称
2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]-N-(4-methyl-2-oxochromen-7-yl)acetamide
英文别名
——
2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]-N-(4-methyl-2-oxochromen-7-yl)acetamide化学式
CAS
1130160-92-7
化学式
C23H19Cl2NO5
mdl
——
分子量
460.314
InChiKey
MBKUBBPGSVNSGE-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    5
  • 重原子数:
    31
  • 可旋转键数:
    7
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.17
  • 拓扑面积:
    81.7
  • 氢给体数:
    1
  • 氢受体数:
    5

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为产物:
    参考文献:
    名称:
    Amide derivatives of ethacrynic acid: Synthesis and evaluation as antagonists of Wnt/β-catenin signaling and CLL cell survival
    摘要:
    A series of amides of ethacrynic acid was prepared and evaluated for their ability to inhibit Wnt signaling and decrease the survival of CLL cells. Several of the most potent derivatives were active in the low micromolar range. Reduction of the alpha,beta-unsaturated carbon-carbon double bond of EA abrogated both the inhibition of Wnt signaling as well as the decrease in CLL survival. Preliminary mechanism of action studies suggest that these derivatives covalently modify sulfhydryl groups present on transcription factors important for Wnt/beta-catenin signaling. (c) 2008 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmcl.2008.12.067
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文献信息

  • Amide derivatives of ethacrynic acid: Synthesis and evaluation as antagonists of Wnt/β-catenin signaling and CLL cell survival
    作者:Guangyi Jin、Desheng Lu、Shiyin Yao、Christina C.N. Wu、Jerry X. Liu、Dennis A. Carson、Howard B. Cottam
    DOI:10.1016/j.bmcl.2008.12.067
    日期:2009.2
    A series of amides of ethacrynic acid was prepared and evaluated for their ability to inhibit Wnt signaling and decrease the survival of CLL cells. Several of the most potent derivatives were active in the low micromolar range. Reduction of the alpha,beta-unsaturated carbon-carbon double bond of EA abrogated both the inhibition of Wnt signaling as well as the decrease in CLL survival. Preliminary mechanism of action studies suggest that these derivatives covalently modify sulfhydryl groups present on transcription factors important for Wnt/beta-catenin signaling. (c) 2008 Elsevier Ltd. All rights reserved.
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