(E)-6-(3-chlorophenyl)hex-5-enoic acid | 81077-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-6-(3-chlorophenyl)hex-5-enoic acid
• CAS: 81077-31-8
• 化学式: C₁₂H₁₃ClO₂
• 分子量: 224.687
• InChiKey: CIMAQPKTSYAJSQ-GORDUTHDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-6-(3-chlorophenyl)hex-5-enoic acid 生成 methyl (E)-6-(3-chlorophenyl)hex-5-enoate
  参考文献：
  名称：

  MARYANOFF, B. E.;DUHL-EMSWILER, B. A., TETRAHEDRON LETT., 1981, 22, N 42, 4185-4188

  摘要：

  DOI：
• 作为产物：
  描述：

  4-羧丁基三苯基溴化膦 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 生成 (E)-6-(3-chlorophenyl)hex-5-enoic acid
  参考文献：
  名称：

  Trans stereoselectivity in the reaction of (4-carboxybutylidene)triphenylphosphorane with aromatic aldehydes

  摘要：

  DOI：

  10.1016/s0040-4039(01)82099-2

文献信息

• Olefination of Aromatic Carbonyls via Site‐Specific Activation of Cycloalkanone Ketals**
  作者：Tuong Anh To、Thanh Vinh Nguyen

  DOI：10.1002/anie.202317003

  日期：2024.1.2

  A simple substrate design allows site-specific activation of cyclic ketones for olefination reaction of aromatic carbonyl compounds.

  简单的底物设计允许环酮的位点特异性活化，用于芳香族羰基化合物的烯化反应。
• INDOLE ANALOGS AS 5-OXO-ETE RECEPTOR ANTAGONISTS AND METHOD OF USE THEREOF
  申请人：THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY

  公开号：US20180086702A1

  公开（公告）日：2018-03-29

  This invention relates to novel pharmaceutically-useful compounds, to methods for their preparation, and to pharmaceutical compositions and therapeutic methods for treating certain conditions.
• [EN] INDOLE ANALOGS AS 5-OXO-ETE RECEPTOR ANTAGONISTS AND METHOD OF USE THEREOF<br/>[FR] ANALOGUES D'INDOLE EN TANT QU'ANTAGONISTES DES RÉCEPTEURS 5-OXO-ETE ET PROCÉDÉ D'UTILISATION DE CEUX-CI
  申请人：THE ROYAL INST FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV

  公开号：WO2016154749A1

  公开（公告）日：2016-10-06

  The present disclosure relates to indole analogs of Formula I as 5-oxo-ETE receptor antagonists wherein R1, R2, Ra, Rb, L, X, m and n are as defined herein. Methods for the preparation of compounds of Formula I, pharmaceutical compositions comprising such compounds and their use for the treatment of conditions related to 5-oxo-ETE receptors are also disclosed. The compounds are useful for the treatment or prophylaxis of a disease or condition selected from asthma, allergic rhinitis, chronic obstructive pulmonary disorder, atopic dermatitis, psoriasis and acne.
• Trans stereoselectivity in the reaction of (4-carboxybutylidene)triphenylphosphorane with aromatic aldehydes
  作者：Bruce E. Maryanoff、Barbara A. Duhl-Emswiler

  DOI：10.1016/s0040-4039(01)82099-2

  日期：——
• MARYANOFF, B. E.;DUHL-EMSWILER, B. A., TETRAHEDRON LETT., 1981, 22, N 42, 4185-4188
  作者：MARYANOFF, B. E.、DUHL-EMSWILER, B. A.

  DOI：——

  日期：——