tert-butyl N-benzyl-N-[4-(furan-2-yl)butyl]carbamate | 1338347-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-benzyl-N-[4-(furan-2-yl)butyl]carbamate
• CAS: 1338347-08-2
• 化学式: C₂₀H₂₇NO₃
• 分子量: 329.439
• InChiKey: VUAYSWFBQRPIJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  42.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 盐酸 、 lithium aluminium tetrahydride 、 Zeise's dimer 、 水 、 对甲苯磺酸 、 三乙胺 、 sodium hydroxide 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 二氯甲烷 、 水 为溶剂， 40.0 ℃ 、101.33 kPa 条件下， 反应 26.5h， 生成 tert-butyl N-benzyl-N-[4-(furan-2-yl)butyl]carbamate
  参考文献：
  名称：

  Generation of α,β-Unsaturated Platinum Carbenes from Homopropargylic Alcohols: Rearrangements to Polysubstituted Furans

  摘要：

  A number of diversely substituted furans are synthesized via a cycloisomerization process that goes through a unique metal carbene species. Both ligand structure and the nature of the leaving group are evaluated. The characteristics of the carbene intermediate can be modulated, resulting in highly selective hydrogen or silicon group migrations.

  DOI：

  10.1021/ol202649j

文献信息

• SOMATOSTATIN ANALOGUE COMPOUNDS
  申请人：ChemBridge Research Laboratories, Inc.

  公开号：EP1549309A2

  公开（公告）日：2005-07-06
• EP1549309A4
  申请人：——

  公开号：EP1549309A4

  公开（公告）日：2006-05-17
• [EN] SOMATOSTATIN ANALOGUE COMPOUNDS<br/>[FR] COMPOSES ANALOGUES DE LA SOMATOSTATINE
  申请人：CHEMBRIDGE RES LAB LLC

  公开号：WO2003090677A2

  公开（公告）日：2003-11-06

  Compounds having somatostatin activity of the following Formula I, wherein, R1 is aryl, substituted-aryl, and aryl­(lower-alkyl)-; R2 is lower alkyl, amino substituted lower alkyl, -carboxy-(lower-alkyl), -carbamic acid-(lower­ alkyl) and -carboxy-(lower-alkyl)-aryl; and R3 and R4 are independently, lower-alkyl, aryl, substituted-aryl, (substituted-aryl)-(lower­alkyl)-, heteroaryl, (heteroaryl)-(lower-alkyl)-, substituted-heteroaryl, (substituted heteroaryl)-(lower-alkyl)-, heterocyclic, heterocyclic-(lower-alkyl)-, substituted-heterocyclic, (substituted-heterocylic) -(lower alkyl)-, -carboxy-(lower-alkyl), and -carboxy-(lower-alkyl)-aryl; or a pharmaceutically acceptable, ester, ether, or salt thereof; methods for their use; and preparation.
• Generation of α,β-Unsaturated Platinum Carbenes from Homopropargylic Alcohols: Rearrangements to Polysubstituted Furans
  作者：Paul A. Allegretti、Eric M. Ferreira

  DOI：10.1021/ol202649j

  日期：2011.11.4

  A number of diversely substituted furans are synthesized via a cycloisomerization process that goes through a unique metal carbene species. Both ligand structure and the nature of the leaving group are evaluated. The characteristics of the carbene intermediate can be modulated, resulting in highly selective hydrogen or silicon group migrations.