2-methoxy-3-pentyloxypropan-1-ol | 140467-70-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 2-methoxy-3-pentyloxypropan-1-ol
• 英文别名: 2-methoxy-3-pentoxypropan-1-ol
• CAS: 140467-70-5
• 化学式: C₉H₂₀O₃
• 分子量: 176.256
• InChiKey: MATYFZRZOZGONW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxy-3-pentyloxypropan-1-ol 在 sodium acetate 、 三乙胺 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 反应 19.0h， 生成 Phosphoric acid 3-bromomethyl-phenyl ester 2-methoxy-3-pentyloxy-propyl ester
  参考文献：
  名称：

  Analogs of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor

  摘要：

  A series of aryl phosphoglyceride (3, 19-6 1) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in which the position of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected compounds were also evaluated for their ability to displace [H-3]PAF from its receptor on rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in both the mouse and rabbit, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Compound 105 (CL 184005) has been selected to undergo further development as a potential therapeutic agent for the treatment of septic shock in man.

  DOI：

  10.1021/jm00087a023
• 作为产物：
  描述：

  甲苯-4-磺酸戊酯 在 吡啶 、 amberlyst-15 、 硫酸 、 sodium hydride 、 sodium iodide 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 57.0h， 生成 2-methoxy-3-pentyloxypropan-1-ol
  参考文献：
  名称：

  Analogs of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor

  摘要：

  A series of aryl phosphoglyceride (3, 19-6 1) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in which the position of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected compounds were also evaluated for their ability to displace [H-3]PAF from its receptor on rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in both the mouse and rabbit, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Compound 105 (CL 184005) has been selected to undergo further development as a potential therapeutic agent for the treatment of septic shock in man.

  DOI：

  10.1021/jm00087a023

文献信息

• PERFUMES IN THE FORM OF AQUEOUS MICROEMULSIONS
  申请人：CHANEL PARFUMS BEAUTE

  公开号：US20200323749A1

  公开（公告）日：2020-10-15

  Disclosed is a microemulsion of oil-in-water type including, preferably consisting of, by weight relative to the total weight of microemulsion: • 70% to 94% of water, • 1% to 15% of at least one hydrophobic fragrancing substance, • 4% to 20% of at least one preferably volatile solvo-surfactant, and • 0.1% to 15%, preferably 1% to 13%, of at least one hydrotropic agent or at least one surfactant selected from anionic surfactants, cationic surfactants, amphoteric surfactants and non-ionic surfactants. The solvo-surfactant is selected from monoalkylated glycerol derivatives of following formula (I): wherein the “alkyl” group is a linear or branched alkyl group including from 1 to 8 carbon atoms, and R and R′ are each independently H or a linear or branched alkyl group including from 1 to 5 carbon atoms, with the proviso that R is different from R′, and mixtures thereof.

  公开了一种油包水型微乳液，包括，相对于微乳液的总重量，优选包括： • 70%至94%的水， • 1%至15%的至少一种疏水香料物质， • 4%至20%的至少一种优选挥发性溶剂表面活性剂，以及 • 0.1%至15%，优选1%至13%的至少一种增溶剂或至少一种选择自阴离子表面活性剂、阳离子表面活性剂、两性表面活性剂和非离子表面活性剂的表面活性剂。溶剂表面活性剂选择自以下化学式（I）的单烷基甘油衍生物：其中“烷基”基团是包括1至8个碳原子的直链或支链烷基基团，R和R'各自独立地是H或包括1至5个碳原子的直链或支链烷基基团，但R与R'不同，并且它们的混合物。
• Perfumes in the form of aqueous microemulsions
  申请人：CHANEL PARFUMS BEAUTE

  公开号：US11052025B2

  公开（公告）日：2021-07-06

  Disclosed is a microemulsion of oil-in-water type including, preferably consisting of, by weight relative to the total weight of microemulsion: •70% to 94% of water, •1% to 15% of at least one hydrophobic fragrancing substance, •4% to 20% of at least one preferably volatile solvo-surfactant, and •0.1% to 15%, preferably 1% to 13%, of at least one hydrotropic agent or at least one surfactant selected from anionic surfactants, cationic surfactants, amphoteric surfactants and non-ionic surfactants. The solvo-surfactant is selected from monoalkylated glycerol derivatives of following formula (I): wherein the “alkyl” group is a linear or branched alkyl group including from 1 to 8 carbon atoms, and R and R′ are each independently H or a linear or branched alkyl group including from 1 to 5 carbon atoms, with the proviso that R is different from R′, and mixtures thereof.

  本发明公开了一种水包油型微乳液，按相对于微乳液总重量的重量计，该微乳液包括，优选由以下成分组成：-70%至 94%的水、-1%至 15%的至少一种疏水性芳香物质、-4%至 20%的至少一种优选挥发性溶剂表面活性剂，以及-0.1%至 15%，优选 1%至 13%的至少一种亲水剂或至少一种选自阴离子表面活性剂、阳离子表面活性剂、两性表面活性剂和非离子表面活性剂的表面活性剂。溶解表面活性剂选自下式 (I) 的单烷基化甘油衍生物： 其中 "烷基 "是包括 1 至 8 个碳原子的直链或支链烷基，R 和 R′各自独立地为 H 或包括 1 至 5 个碳原子的直链或支链烷基，但 R 与 R′不同，以及它们的混合物。
• Process for dehydrating gas
  申请人：——

  公开号：US20040139855A1

  公开（公告）日：2004-07-22

  A process for the removal of water from gas which comprises an absorption step of bringing a gas ( 1 ) saturated with water vapour into gas-liquid contact with a water-lean absorbing liquid ( 3 ) comprising a water absorbing liquid having a cloud point temperature above the freezing point of water whereby water vapour present in the gas is absorbed into the water-lean absorbing liquid at a temperature below its cloud point to produce a refined gas ( 4 ) having a reduced water vapour content and water-loaded absorbing liquid ( 5 ); and a regeneration step of heating the water-loaded absorbing liquid ( 5 ) to above the cloud point temperature of the absorbing liquid whereby the water-loaded absorbing liquid separates into a water-rich phase ( 7 ) and an absorbing liquid-rich phase ( 8 ) and cooling the absorbing liquid-rich phase to a temperature below its cloud point prior to recycling the absorbing liquid-rich phase for use as water-lean absorbing liquid ( 3 ) in the absorption step.

  一种从气体中去除水分的工艺，包括一个吸收步骤，将气体 ( 1 )饱和水蒸气与不含水分的吸收液( 3 其中吸水液体的浊点温度高于水的凝固点，气体中的水蒸气在低于浊点的温度下被吸水液体吸收，从而产生精制气体 ( 4 水蒸气含量降低的精制气体和含水吸收液 ( 5 ) ；再生步骤是加热含水吸收液 ( 5 ) 至高于吸收液的浊点温度，从而使含水吸收液分离成富水相 ( 7 ) 和富含吸收液的相 ( 8 将富吸收液相冷却至低于其浊点温度，然后将富吸收液相回收用作水浸吸收液 ( 3 ) 在吸收步骤中使用。
• PROCESS FOR DEHYDRATING GAS
  申请人：BP EXPLORATION OPERATING COMPANY LIMITED

  公开号：EP1372824B1

  公开（公告）日：2004-08-11
• PARFUMS SOUS FORME DE MICROÉMULSIONS AQUEUSES
  申请人：Chanel Parfums Beauté

  公开号：EP3463585B1

  公开（公告）日：2020-07-08