N-phenylacetyl-DL-penicillamine | 158298-55-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-phenylacetyl-DL-penicillamine
• 英文别名: N-phenylacetyl-penicillamine；3-Methyl-2-[(2-phenylacetyl)amino]-3-sulfanylbutanoic acid
• CAS: 158298-55-6
• 化学式: C₁₃H₁₇NO₃S
• 分子量: 267.349
• InChiKey: MTYUIPPHWJZKDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-phenylacetyl-DL-penicillamine 在 氯仿 、 三乙胺 、 氯甲酸异丁酯 作用下， 生成 4,4-dimethyl-3-(phenylacetyl-amino)-thietan-2-one
  参考文献：
  名称：

  Effect of Mn cluster on the formation of Superoxide radicals in photoinhibition of photosystem II

  摘要：

  To further realize the action of superoxide radicals (O-2(-.)) in photoinhibition of photosystem II (PS II), we employed 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as a spin trap, associated with EPR spectroscopy, to study the effect of illumination time on O-2(-.) formation during high light photoinhibition in PS II membranes and Mn-depleted PS II membranes. Results indicated that the removal of Mn cluster from PS II membranes has a strong influence on the dynamics of superoxide formation. The relative mechanism was also discussed. These novel findings may further promote the studies of the structure and function of PS II and the mechanism of photoinhibition.

  DOI：

  10.1007/bf02901162
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 、 sodium 作用下， 生成 N-phenylacetyl-DL-penicillamine
  参考文献：
  名称：

  Behrens et al., Journal of Biological Chemistry, 1948, vol. 175, p. 771,778

  摘要：

  DOI：

文献信息

• Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase
  作者：Sakina Bounaga、Moreno Galleni、Andrew P Laws、Michael I Page

  DOI：10.1016/s0968-0896(00)00257-1

  日期：2001.2

  Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta -lactamase. The pH dependence of pK(i) indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Knunjanz; Lin'kowa, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1955, p. 62,68; lengl. Ausg. S. 53, 57
  作者：Knunjanz、Lin'kowa

  DOI：——

  日期：——
• Behrens et al., Journal of Biological Chemistry, 1948, vol. 175, p. 771,778
  作者：Behrens et al.

  DOI：——

  日期：——
• Effect of Mn cluster on the formation of Superoxide radicals in photoinhibition of photosystem II
  作者：Suping Zhang、Tiecheng Tu、Jun Weng、Jingxi Pan、Chunhe Xu、Side Yao

  DOI：10.1007/bf02901162

  日期：2001.11

  To further realize the action of superoxide radicals (O-2(-.)) in photoinhibition of photosystem II (PS II), we employed 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as a spin trap, associated with EPR spectroscopy, to study the effect of illumination time on O-2(-.) formation during high light photoinhibition in PS II membranes and Mn-depleted PS II membranes. Results indicated that the removal of Mn cluster from PS II membranes has a strong influence on the dynamics of superoxide formation. The relative mechanism was also discussed. These novel findings may further promote the studies of the structure and function of PS II and the mechanism of photoinhibition.