bis(3-hydroxypropyl) telluride | 130418-20-1

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: bis(3-hydroxypropyl) telluride
• 英文别名: di(3-hydroxypropyl)telluride；3-(3-Hydroxypropyltellanyl)propan-1-ol
• CAS: 130418-20-1
• 化学式: C₆H₁₄O₂Te
• 分子量: 245.776
• InChiKey: GSVXMIHIVWZIDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.29
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bis(3-hydroxypropyl) telluride 在 叔丁基过氧化氢 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.58h， 以94%的产率得到1,6-dioxa-5λ⁴-tellura-spiro[4.4]nonane
  参考文献：
  名称：

  WO2007/44641

  摘要：

  公开号：
• 作为产物：
  描述：

  3-溴-1-丙醇 在 sodium hydroxide 、 碲化氢 、 rongalite 作用下， 以 水 为溶剂， 反应 0.58h， 以55%的产率得到bis(3-hydroxypropyl) telluride
  参考文献：
  名称：

  Aromatic Derivatives and Tellurium Analogues of Cyclic Seleninate Esters and Spirodioxyselenuranes That Act as Glutathione Peroxidase Mimetics

  摘要：

  Several novel organoselenium and tellurium compounds were prepared and evaluated as mimetics of the selenoenzyme glutathione peroxidase, which protects cells from oxidative stress by reducing harmful peroxides with the thiol glutathione. The compounds were tested for catalytic activity in a model system wherein tert-butyl hydroperoxide or hydrogen peroxide were reduced with benzyl thiol and the rate of the reaction was measured by monitoring the formation of dibenzyl disulfide. Thus, aromatic derivatives 19, 22, 24, and 25 proved to be inferior catalysts compared to the parent cyclic seleninate ester 14 and spirodioxyselenurane 16. In the case of 19 and 22, this was the result of their rapid conversion to the relatively inert selenenyl sulfides 31 and 32, respectively. In general, hydrogen peroxide was reduced faster than tert-butyl hydroperoxide in the presence of the selenium-based catalysts. The cyclic tellurinate ester 27 and spirodioxytellurane 29 proved to be superior catalysts to their selenium analogues 14 and 16, respectively, resulting in the fastest reaction rates by far of all of the compounds we have investigated to date. Oxidation of 29 with hydrogen peroxide produced the unusual and unexpected peroxide 33, in which two hypervalent octahedral tellurium moieties are joined by ether and peroxide bridges. The structure of 33 was confirmed by X-ray crystallography. Although 33 displayed strong catalytic activity when tested independently in the model system, its relatively slow formation from the oxidation of 29 rules out its intermediacy in the catalytic cycle of 29.

  DOI：

  10.1021/jo0512711

文献信息

• A facile access to chalcogen and dichalcogen bearing dialkylamines and diols
  作者：Marilyn Daisy Milton、Shabana Khan、Jai Deo Singh、Vivek Mishra、Bishan Lal Khandelwal

  DOI：10.1016/j.tetlet.2004.12.035

  日期：2005.1

  A highly practical procedure for the preparation of novel classes of chalcogen bearing diamines [H2N(CH2)n}E] and diols [HO(CH2)n}(2)E] (n = 2 or 3 and E = Se or Te) by the reaction of disodiumchalcogenide and haloalkylamines or haloalcohols is presented. (C) 2004 Elsevier Ltd. All rights reserved.