1,3-二(4-氨基磺酰基苯基)三氮烯 | 5433-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,3-二(4-氨基磺酰基苯基)三氮烯
• 英文名称: 4,4'-triazenediyl-bis-benzenesulfonic acid diamide
• 英文别名: N.N'-Bis-(4-sulfamoyl-phenyl)-triazen；Diazoaminobenzol-disulfonsaeure-(4.4')-diamid；4,4'-Triazendiyl-bis-benzolsulfonsaeure-diamid；1,3-Di(4-sulfamoylphenyl)triazene；4-[2-(4-sulfamoylphenyl)iminohydrazinyl]benzenesulfonamide
• CAS: 5433-44-3
• 化学式: C₁₂H₁₃N₅O₄S₂
• 分子量: 355.398
• InChiKey: WKKNCBFGLHEOCW-UHFFFAOYSA-N

物化性质

• 沸点：
  613.4±65.0 °C(Predicted)
• 密度：
  1.4856 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  174
• 氢给体数：
  3
• 氢受体数：
  9

安全信息

• 海关编码：
  2935009090

反应信息

• 作为产物：
  描述：

  磺胺 在 盐酸 、 sodium acetate 、 sodium nitrite 作用下， 生成 1,3-二(4-氨基磺酰基苯基)三氮烯
  参考文献：
  名称：

  Electrochemical investigation of some potential antibacterials, II

  摘要：

  2-(4'-磺酰胺基)酰肼丁酸-1,3-二酮和磺酰胺基偶氮氨基苯的电化学行为在滴汞电极和玻璃碳电极上在广泛的pH范围内进行了研究。这两种化合物在两种电极上都表现出4e⁻还原反应。在pH>4.5时，2-(4'-磺酰胺基)酰肼丁酸-1,3-二酮在更高的电位上表现出2e⁻还原波。这两种化合物都经历了2e⁻氧化反应。基于极谱法、线性和循环伏安法、控制电位电解、库仑计量和光谱分析，已经提出了还原和氧化的详细机理。关键词：电化学、磺酰胺、极谱法、循环伏安法、库仑计量。

  DOI：

  10.1139/v97-067

文献信息

• Electrochemical investigation of some potential antibacterials, II
  作者：Rajeev Jain、P. Padmaja、Seema Gupta

  DOI：10.1139/v97-067

  日期：1997.5.1

  The electrochemical behaviour of 2-(4′-sulphonamoyl)hydrazonobutyrate-1,3-diones and sulphonamoylazoaminobenzenes has been studied over a wide range of pH at dropping mercury as well as glassy carbon electrodes. Both types of compounds exhibited a 4e⁻ reduction reaction at both electrodes. At pH > 4.5, 2-(4′-sulphonamoyl)hydrazonobutyrate-1,3-diones exhibited a 2e⁻ reduction wave at higher potentials. Both compounds undergo a 2e⁻ oxidation reaction. On the basis of polarography, linear and cyclic voltammetry, controlled potential electrolysis, coulometry, and spectral analysis, a detailed mechanism has been postulated for the reduction as well as the oxidation. Keywords: electrochemistry, sulphonamides, polarography, cyclic voltammetry, coulometry.

  2-(4'-磺酰胺基)酰肼丁酸-1,3-二酮和磺酰胺基偶氮氨基苯的电化学行为在滴汞电极和玻璃碳电极上在广泛的pH范围内进行了研究。这两种化合物在两种电极上都表现出4e⁻还原反应。在pH>4.5时，2-(4'-磺酰胺基)酰肼丁酸-1,3-二酮在更高的电位上表现出2e⁻还原波。这两种化合物都经历了2e⁻氧化反应。基于极谱法、线性和循环伏安法、控制电位电解、库仑计量和光谱分析，已经提出了还原和氧化的详细机理。关键词：电化学、磺酰胺、极谱法、循环伏安法、库仑计量。
• Gray; Buttle; Stephenson, Biochemical Journal, 1937, vol. 31, p. 724,727
  作者：Gray、Buttle、Stephenson

  DOI：——

  日期：——
• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.