N,N-diisobutyl-glycine | 23590-04-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-diisobutyl-glycine
• 英文别名: N,N-Diisobutyl-glycin；2-[Bis(2-methylpropyl)azaniumyl]acetate
• CAS: 23590-04-7
• 化学式: C₁₀H₂₁NO₂
• 分子量: 187.282
• InChiKey: ULZYXTQXAOPNIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为产物：
  描述：

  异丁醛 、 聚甘氨酸 在 乙醇 、 2-(异丁基氨基)乙酸 、 钯 作用下， 生成 N,N-diisobutyl-glycine
  参考文献：
  名称：

  �ber die Zersetzung von ?-Amino-N-carbons�ureanhydriden mit Pyridin und Pyridinderivaten. (Zur Frage der Bildung von h�hermolekularen Cyklopeptiden)

  摘要：

  DOI：

  10.1007/bf00902771

文献信息

• OXADIAZOLE DERIVATIVES
  申请人：Quattropani Anna

  公开号：US20120022109A1

  公开（公告）日：2012-01-26

  The invention relates to oxadiazole compounds of formula I. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.

  该发明涉及式I的噁唑烷化合物。该化合物在治疗自身免疫性疾病，如多发性硬化症等方面是有用的。
• Anti-fibril peptides
  申请人：Hammer P. Robert

  公开号：US20050119187A1

  公开（公告）日：2005-06-02

  Short peptides containing C α,α -dipropylglycine (Dpg) at alternating sequence positions were synthesized and examined for conformational behavior. Peptide assembly was performed using Fmoc-solid-phase chemistry where the coupling with PyAOP could be significantly enhanced at elevated temperature. Circular dichroism (CD) and NMR conformational studies revealed that incorporation of Dpg residues induced folded structures into peptides. It was observed that Dpg residues adopted helical conformation in a helix-promoting sequence. The resulting helical structure was comprised of consecutive β-turns whose structure was stabilized by salt bridge in aqueous solution. In this study, the preparation of sterically and polyfunctional C α,α -disubstituted amino acids (ααAAs) via alkylation of ethyl nitroacetate and transformation into derivatives ready for incorporation into peptides are described. Treatment of ethyl nitroacetate with N,N-diisopropylethylamine in the presence of a catalytic amount of tetraalkylammonium salt, followed by the addition of an activated alkyl halide or Michael acceptor, gave the doubly C-alkylated product in good to excellent yields. Selective nitro reduction with Zn in acetic or hydrogen over Raney Ni gave the corresponding amino ester that, upon saponification, can be protected with the fluorenylmethyloxycarbonyl (Fmoc) group. The synthesis of a sterically demanding C α,α -dibenzylglycine (Dbzg), and an orthogonally protected, tetrafunctional C α,α -disubstituted analogue of aspartic acid Bcmg is described. The preparation of amyloid fibril blocker peptides based on amyloid peptide hydrophobic core Aβ 16-20 is described. These blocker peptides containing sterically

  含有Cα，α-二丙基甘氨酸（Dpg）的短肽序列被合成并检测其构象行为。肽组装使用Fmoc固相化学方法进行，其中与PyAOP的偶联可以在升高的温度下显著增强。圆二色性（CD）和NMR构象研究表明，Dpg残基的引入使肽中产生了折叠结构。观察到Dpg残基在螺旋促进序列中采用螺旋构象。所得到的螺旋结构由连续的β-转角组成，在水溶液中由盐桥稳定其结构。本研究介绍了通过乙基硝酸酯的烷基化和转化成准备好用于肽中的衍生物来制备立体和多功能的Cα，α-二取代氨基酸（ααAAs）的方法。在四烷基铵盐的催化下，将乙基硝酸酯与N，N-二异丙基乙基胺反应，然后加入活化的烷基卤或迈克尔受体，以良好至优良的收率得到双重C-烷基化产物。在乙酸或Raney Ni的氢中，用Zn选择性还原硝基，得到相应的氨基酸酯，经皂化后可以用芴甲氧羰基（Fmoc）基团保护。介绍了一种立体要求高的Cα，α-二苄基甘氨酸（Dbzg）和一个正交保护的、四功能的Cα，α-二取代天冬氨酸类似物Bcmg的合成方法。介绍了基于淀粉样蛋白肽疏水核心Aβ16-20的淀粉样纤维阻滞肽的制备方法。这些阻滞肽含有立体的残基，可以阻止淀粉样纤维的形成。
• SUBSTRATE CLEANER FOR COPPER WIRING, AND METHOD FOR CLEANING COPPER WIRING SEMICONDUCTOR SUBSTRATE
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP2647693A1

  公开（公告）日：2013-10-09

  It is an object of the present invention to provide a cleaning agent for a substrate having a copper wiring, which makes possible to sufficiently suppress elution of metal copper, and remove impurities or particles of copper hydroxide (II), copper oxide (II) and the like, generated by the chemical mechanical polishing (CMP) process, in cleaning of a semiconductor substrate after the chemical mechanical polishing (CMP) process, in a manufacturing process of the semiconductor substrate; and a method for cleaning a semiconductor substrate having a copper wiring, characterized by using the relevant substrate cleaner for a copper wiring: and the present invention relates to a cleaning agent for a substrate having a copper wiring consisting of an aqueous solution comprising [I] an amino acid represented by the following general formula [1], and [II] an alkylhydroxylamine; and a method for cleaning a semiconductor substrate having a copper wiring characterized by using the relevant cleaning agent for a substrate having a copper wiring; (wherein R1 represents a hydrogen atom, a carboxymethyl group or a carboxyethyl group; and R2 and R3 each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, which may have a hydroxyl group, provided that those where R1 to R3 are all hydrogen atoms are excluded.).

  本发明的目的是提供一种用于具有铜布线的衬底的清洗剂，该清洗剂能够在半导体衬底的制造过程中，在化学机械抛光(CMP)工序后清洗半导体衬底时，充分抑制金属铜的洗脱，并除去化学机械抛光(CMP)工序产生的氢氧化铜(II)、氧化铜(II)等杂质或颗粒；以及一种用于清洗具有铜布线的半导体衬底的方法，其特征在于使用相关的用于铜布线的衬底清洗剂：以及本发明涉及一种用于具有铜布线的衬底的清洁剂，该清洁剂由水溶液组成，该水溶液包含[I]由以下通式[1]表示的氨基酸和[II]烷基羟胺；以及一种用于清洁具有铜布线的半导体衬底的方法，其特征在于使用用于具有铜布线的衬底的相关清洁剂； (其中R1代表氢原子、羧甲基或羧乙基；R2和R3各自独立地代表氢原子或具有1至4个碳原子的烷基，该烷基可以具有羟基，但不包括R1至R3均为氢原子的情况)。
• 273. N-substituted amino-acids. Part II. The reductive alkylation of amino-acids
  作者：R. E. Bowman

  DOI：10.1039/jr9500001346

  日期：——
• TREATMENT OF PIGS FOR REDUCING THE FEED CONVERSION RATIO OR INCREASING THE GROWTH RATE
  申请人：Taminco

  公开号：EP2207432A1

  公开（公告）日：2010-07-21