1-溴-4-((8-溴辛基)氧基)苯 | 75612-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-溴-4-((8-溴辛基)氧基)苯
• 英文名称: 1-Bromo-4-(8-bromo-octyloxy)-benzene
• 英文别名: 1-Bromo-4-[(8-bromooctyl)oxy]benzene；1-bromo-4-(8-bromooctoxy)benzene
• CAS: 75612-74-7
• 化学式: C₁₄H₂₀Br₂O
• 分子量: 364.12
• InChiKey: BDZVSLRLAUTHLH-UHFFFAOYSA-N

物化性质

• 沸点：
  396.9±22.0 °C(Predicted)
• 密度：
  1.409±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-溴-4-((8-溴辛基)氧基)苯 以 甲醇 为溶剂， 反应 4.0h， 以59%的产率得到8-苯氧基辛基溴化物
  参考文献：
  名称：

  The mechanism of the photo-induced homolysis of aryl halides

  摘要：

  DOI：

  10.1016/s0040-4039(00)78642-4
• 作为产物：
  描述：

  4-溴苯酚 、 1,8-二溴辛烷 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-溴-4-((8-溴辛基)氧基)苯
  参考文献：
  名称：

  Synthesis and Liquid-crystalline Properties of Bromoalkyloxy-substituted Terphenylenes

  摘要：

  通过芳基硼酸和溴芳基衍生物之间的钯交叉偶联反应，合成了一系列溴烷氧基取代的三苯基。通过DSC观察到这些中间体在很宽的温度范围（110-180°C）内表现出丰富的热致性，通过X射线衍射确定液晶性质对应于倾斜型层状介相（SmC、SmF/SmI和二维有序倾斜介相SmX）。

  DOI：

  10.1246/cl.2006.652

文献信息

• New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity
  作者：Maria P. Paramonova、Robert Snoeck、Graciela Andrei、Anastasia L. Khandazhinskaya、Mikhail S. Novikov

  DOI：10.1016/j.mencom.2020.09.016

  日期：2020.9

  New N-aryl-2-3-[ω-(4-bromophenoxy)alkyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}acetamides have been obtained from 1-[ω-(4-bromophenoxy)alkyl]uracil and 2-chloro-N-(4-phenoxyphenyl)acetamide derivatives. Investigation of their antiviral properties against human cytomegalovirus revealed that the representative with dodecane-1,12-diyl linker exhibited powerful virus inhibitory activity in vitro.

  从1- [ω- （4-溴苯氧基）烷基]尿嘧啶和2-氯-N-（4-苯氧基苯基）乙酰胺衍生物。他们对人类巨细胞病毒的抗病毒特性的调查表明，具有十二烷-1,12-二基接头的代表在体外表现出强大的病毒抑制活性。
• Synthesis and Liquid-crystalline Properties of Bromoalkyloxy-substituted Terphenylenes
  作者：Leticia Larios-López、Dámaso Navarro-Rodríguez、Bertrand Donnio、Daniel Guillon

  DOI：10.1246/cl.2006.652

  日期：2006.6

  A series of bromoalkyloxy-substituted terphenylenes were synthesized through a Palladium cross-coupling reaction between arylboronic acids and bromoaryl derivatives. By DSC it was observed that these intermediates show a rich thermotropism in a wide range of temperature (110–180 °C) and by X-ray diffraction it was determined that the liquid-crystalline nature corresponds to tilted type smectic mesophases (SmC, SmF/SmI, and a two-dimensional ordered tilted mesophase SmX).

  通过芳基硼酸和溴芳基衍生物之间的钯交叉偶联反应，合成了一系列溴烷氧基取代的三苯基。通过DSC观察到这些中间体在很宽的温度范围（110-180°C）内表现出丰富的热致性，通过X射线衍射确定液晶性质对应于倾斜型层状介相（SmC、SmF/SmI和二维有序倾斜介相SmX）。
• Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
  作者：Mikhail S. Novikov、Denis A. Babkov、Maria P. Paramonova、Anastasia L. Khandazhinskaya、Alexander A. Ozerov、Alexander O. Chizhov、Graciela Andrei、Robert Snoeck、Jan Balzarini、Katherine L. Seley-Radtke

  DOI：10.1016/j.bmc.2013.05.009

  日期：2013.7

  HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[omega-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC50 values within 5.5-12 mu M range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure-activity relationship for the linker region. (C) 2013 Elsevier Ltd. All rights reserved.
• CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1173472A1

  公开（公告）日：2002-01-23
• US6884868B1
  申请人：——

  公开号：US6884868B1

  公开（公告）日：2005-04-26