5-[(2,6-dichlorophenyl)methylidene]-2-[(4-methoxyphenyl)methylamino]-1H-imidazol-4-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-[(2,6-dichlorophenyl)methylidene]-2-[(4-methoxyphenyl)methylamino]-1H-imidazol-4-one
• 化学式: C₁₈H₁₅Cl₂N₃O₂
• 分子量: 376.242
• InChiKey: RARWLDVGBMURJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.62
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  62.72
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  5-(2,6-dichlorobenzylidene)-2-thiohydantoin 在 sodium ethanolate 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 9.5h， 生成 5-[(2,6-dichlorophenyl)methylidene]-2-[(4-methoxyphenyl)methylamino]-1H-imidazol-4-one
  参考文献：
  名称：

  Antimicrobial activity of 5-arylidene aromatic derivatives of hydantoin. Part 2

  摘要：

  Various 5-chloroarylidene-2-amino substituted derivatives of imidazoline-4-one were synthesized and evaluated for their activity in vitro against Mycobacterium tuberculosis and other type strains of bacteria and fungi. 2-Chloro- and 2,4-dichlorobenzylidene substituted hydantoins exhibited antimycobacterial effect. The most potent compounds 3i, 3j, 3o, 3q and 3s were classified for further tests. The antimitotic effect of the investigated hydantoins was also examined. (C) 2002 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01172-7

文献信息

• Antimicrobial activity of 5-arylidene aromatic derivatives of hydantoin. Part 2
  作者：Ewa Szymańska、Katarzyna Kieć-Kononowicz、Anna Białecka、Andrzej Kasprowicz

  DOI：10.1016/s0014-827x(01)01172-7

  日期：2002.1

  Various 5-chloroarylidene-2-amino substituted derivatives of imidazoline-4-one were synthesized and evaluated for their activity in vitro against Mycobacterium tuberculosis and other type strains of bacteria and fungi. 2-Chloro- and 2,4-dichlorobenzylidene substituted hydantoins exhibited antimycobacterial effect. The most potent compounds 3i, 3j, 3o, 3q and 3s were classified for further tests. The antimitotic effect of the investigated hydantoins was also examined. (C) 2002 Elsevier Science S.A. All rights reserved.