2-Amino-succinic acid 1-tert-butyl ester 4-methyl ester | 126181-44-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-succinic acid 1-tert-butyl ester 4-methyl ester
• 英文别名: 1-(1,1-Dimethylethyl) 4-methyl aspartate；1-O-tert-butyl 4-O-methyl 2-aminobutanedioate
• CAS: 126181-44-0
• 化学式: C₉H₁₇NO₄
• 分子量: 203.238
• InChiKey: WNJFEWOMTHUJAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Amino-succinic acid 1-tert-butyl ester 4-methyl ester 在 三氟乙酸 作用下， 生成 4-甲基DL-天冬氨酸氢酯
  参考文献：
  名称：

  N（二苯基亚甲基）草酸叔丁酯合成DL-α-氨基酸的新方法

  摘要：

  DOI：

  10.1016/s0040-4039(00)99404-8
• 作为产物：
  描述：

  1-O-tert-butyl 4-O-methyl 2-(benzhydrylamino)butanedioate 在 palladium on activated charcoal 甲酸 作用下， 以 甲醇 为溶剂， 以71%的产率得到2-Amino-succinic acid 1-tert-butyl ester 4-methyl ester
  参考文献：
  名称：

  N（二苯基亚甲基）草酸叔丁酯合成DL-α-氨基酸的新方法

  摘要：

  DOI：

  10.1016/s0040-4039(00)99404-8

文献信息

• Synthesis of meta-Carboranyl-(S)-homocysteine Sulfoxide
  作者：D. A. Gruzdev、V. O. Ustinova、G. L. Levit、V. A. Ol’shevskaya、V. P. Krasnov

  DOI：10.1134/s1070428018100251

  日期：2018.10

  New (S)-homocysteine derivatives containing a meta-carborane fragment were synthesized. m-Carboranyl-(S)-homocysteine sulfoxide was obtained as a mixture of diastereoisomers. The reduction of the side-chain carboxy group of N-tert-butoxycarbonyl-(S)-aspartic acid -tert-butyl ester with sodium tetrahydridoborate was not accompanied by racemization.
• BAZUREAU, J. P.;PERSON, D.;LE, CORRE M., TETRAHEDRON LETT., 30,(1989) N3, C. 3065-3068
  作者：BAZUREAU, J. P.、PERSON, D.、LE, CORRE M.

  DOI：——

  日期：——
• SUBSTITUTED CYCLIC PYRROLIDINE DERIVATIVES
  申请人：Qiu Yao-Ling

  公开号：US20090324544A1

  公开（公告）日：2009-12-31

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with said compounds.
• New synthesis of DL-α- aminoacids from t-butyl N(diphenylmethylene) oxamate
  作者：J.P. Bazureau、D. Person、M. Le Corre

  DOI：10.1016/s0040-4039(00)99404-8

  日期：1989.1