tert-butyl 3-((1-(3-methoxyphenyl)ethyl)(methyl)amino)propylcarbamate | 903588-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: tert-butyl 3-((1-(3-methoxyphenyl)ethyl)(methyl)amino)propylcarbamate
• 英文别名: (3-{[1-(3-methoxy-phenyl)-ethyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester；(3-{[1-(3-Methoxy-phenyl)-ethyl]-methyl-amino}-propyl)-carbamic acid ter-butyl ester；tert-butyl N-[3-[1-(3-methoxyphenyl)ethyl-methylamino]propyl]carbamate
• CAS: 903588-34-1
• 化学式: C₁₈H₃₀N₂O₃
• 分子量: 322.448
• InChiKey: WUUDSTPIGJRUOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 3-((1-(3-methoxyphenyl)ethyl)(methyl)amino)propylcarbamate 在 三氟乙酸 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 以100%的产率得到N1-(1-(3-methoxyphenyl)ethyl)-N1-methylpropane-1,3-diamine
  参考文献：
  名称：

  Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease

  摘要：

  Lipoic acid (LA) is a natural antioxidant. Its structure was previously combined with that of the acetylcholinesterase inhibitor tacrine to give lipocrine (1), a lead compound multitargeted against Alzheimer's disease (AD). Herein, we further explore LA as a privileged structure for developing multimodal compounds to investigate AD. First, we studied the effect of LA chirality by evaluating the cholinesterase profile of 1's enantiomers. Then, a new series of LA hybrids was designed and synthesized by combining racemic LA with motifs of other known anticholinesterase agents (rivastigmine and memoquin). This afforded 4, which represents a step forward in the search for balanced anticholinesterase and antioxidant capacities. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.09.001
• 作为产物：
  描述：

  1-(3-甲氧基苯基)-N-甲基乙胺 、 N-BOC-3-氯丙基胺 在 potassium carbonate 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以40%的产率得到tert-butyl 3-((1-(3-methoxyphenyl)ethyl)(methyl)amino)propylcarbamate
  参考文献：
  名称：

  Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation

  摘要：

  通式(I)所识别的化合物用于治疗阿尔茨海默病。

  公开号：

  US20070219241A1

文献信息

• Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation
  申请人：Rosini Michela

  公开号：US20070219241A1

  公开（公告）日：2007-09-20

  Compounds identified by the general formula (I) are used for the treatment of Alzheimer's disease.

  通式(I)所识别的化合物用于治疗阿尔茨海默病。
• Tetrahydro-acridine and dithiolane derivatives
  申请人：Alma Mater Studiorum-Universita'di Bologna

  公开号：US07307083B2

  公开（公告）日：2007-12-11

  Compounds identified by the general formula (I) are used for the treatment of Alzheimer's disease

  通式（I）所识别的化合物用于治疗阿尔茨海默病。
• Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
  申请人：Rosini Michela

  公开号：US20070299093A1

  公开（公告）日：2007-12-27

  Compounds identified by the general formula (I) are used for the treatment of Alzheimer's disease.

  通式（I）所识别的化合物被用于治疗阿尔茨海默病。
• US7307083B2
  申请人：——

  公开号：US7307083B2

  公开（公告）日：2007-12-11
• Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease
  作者：Michela Rosini、Elena Simoni、Manuela Bartolini、Andrea Tarozzi、Riccardo Matera、Andrea Milelli、Patrizia Hrelia、Vincenza Andrisano、Maria Laura Bolognesi、Carlo Melchiorre

  DOI：10.1016/j.ejmech.2011.09.001

  日期：2011.11

  Lipoic acid (LA) is a natural antioxidant. Its structure was previously combined with that of the acetylcholinesterase inhibitor tacrine to give lipocrine (1), a lead compound multitargeted against Alzheimer's disease (AD). Herein, we further explore LA as a privileged structure for developing multimodal compounds to investigate AD. First, we studied the effect of LA chirality by evaluating the cholinesterase profile of 1's enantiomers. Then, a new series of LA hybrids was designed and synthesized by combining racemic LA with motifs of other known anticholinesterase agents (rivastigmine and memoquin). This afforded 4, which represents a step forward in the search for balanced anticholinesterase and antioxidant capacities. (C) 2011 Elsevier Masson SAS. All rights reserved.