(R)-5-Brom-4-methyl-pentansaeure | 59781-33-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-5-Brom-4-methyl-pentansaeure
• 英文别名: (R)-5-bromo-4-methylpentanoic acid；(4R)-5-bromo-4-methylpentanoic acid
• CAS: 59781-33-8
• 化学式: C₆H₁₁BrO₂
• 分子量: 195.056
• InChiKey: DCDCGYCMMJLNKE-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲醇 、 (R)-5-Brom-4-methyl-pentansaeure 在 硫酸 作用下， 生成 (R)-甲基-5-溴-4-甲基戊酸酯
  参考文献：
  名称：

  850.肽。第十二部分。4-甲基脯氨酸的立体异构体

  摘要：

  DOI：

  10.1039/jr9620004387
• 作为产物：
  描述：

  (R)-(+)-5-acetoxy-4-methylpentanoic acid 在 硫酸 、 氢溴酸 作用下， 生成 (R)-5-Brom-4-methyl-pentansaeure
  参考文献：
  名称：

  850.肽。第十二部分。4-甲基脯氨酸的立体异构体

  摘要：

  DOI：

  10.1039/jr9620004387

文献信息

• Furan intermediates and process for synthesis of
  申请人：American Cyanamid Company

  公开号：US03952033A1

  公开（公告）日：1976-04-20

  This disclosure describes novel 2,5-dihydro-2,5-dialkoxyfuran derivatives useful as intermediates for the preparation of the natural prostaglandins and their congeners.

  本公开说明了新型2,5-二氢-2,5-二烷氧基呋喃衍生物的用途，可用作天然前列腺素及其同系物的中间体制备。
• 2,5-Dihydro-2,5-dialkoxyfuran derivatives
  申请人：American Cyanamid Company

  公开号：US04021452A1

  公开（公告）日：1977-05-03

  This disclosure describes novel 2,5-dihydro-2,5-dialkoxyfuran derivatives useful as intermediates for the preparation of the natural prostaglandins and their congeners.

  本公开说明了一种新型的2,5-二氢-2,5-二烷氧基呋喃衍生物，可用作合成天然前列腺素及其同系物的中间体。
• Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases
  申请人：——

  公开号：US20040127549A1

  公开（公告）日：2004-07-01

  Compounds of general formula (I), wherein R 1 , R 2 , R 3 , Y, (X) o , (W) n , (V) m , Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds. 1

  通式（I）的化合物，其中R1，R2，R3，Y，（X）o，（W）n，（V）m，Z和U的定义如规范所述，是cruzipain和其他半胱氨酸蛋白酶抑制剂的抑制剂，并且可用作治疗剂，例如在恶性贾格斯病中，或用于验证治疗靶向化合物。
• Substituted cyclodextrin derivatives and process for their preparation
  申请人：Arcarios B.V.

  公开号：EP2550299A2

  公开（公告）日：2013-01-30
• Substituted Cyclodextrin Derivatives Useful As Intermediates For Producing Biologically Active Materials
  申请人：Van Calenbergh Serge

  公开号：US20130046087A1

  公开（公告）日：2013-02-21

  The present invention relates to substituted cyclodextrin derivatives which are particularly useful intermediates for producing well-defined carboxyalkylated cyclodextrins in contrast with the poorly-defined mixtures available through prior art procedures. The present invention also relates to processes for their preparation in a limited number of steps. These well-defined carboxyalkylated cyclodextrins can be polysulfated according to procedures standard in the art and some of these polysulfates, and alkali salts thereof, have been found to exhibit biologically active properties especially for the treatment and/or prophylaxis of degenerative joint diseases (e.g. osteoarthritis) or heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.