methyl 2-hydroxy-2-diethoxyphosphorylamino-3,3,3-trifluoropropionate | 326879-69-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-hydroxy-2-diethoxyphosphorylamino-3,3,3-trifluoropropionate
• 英文别名: methyl 2-(diethoxyphosphorylamino)-3,3,3-trifluoro-2-hydroxypropanoate
• CAS: 326879-69-0
• 化学式: C₈H₁₅F₃NO₆P
• 分子量: 309.179
• InChiKey: WOQCHEZVCGRHSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  94.1
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  methyl 2-hydroxy-2-diethoxyphosphorylamino-3,3,3-trifluoropropionate 在 氯化亚砜 、 三乙胺 作用下， 以 乙醚 、 苯 为溶剂， 反应 4.0h， 生成 methyl 2-(diethoxyphosphoryl)imino-3,3,3-trifluoropropionate
  参考文献：
  名称：

  摘要：

  The first example of trifluoropyruvate phosphorylimines was prepared, and its capability for O- and S-amidoalkylation of water, alcohols, and compounds with the SH function was shown. Phenol and 4-methoxyphenol are O-alkylated, while 3-dimethylaminophenol and indole undergo regiospecific C-alkylation at the site of the highest pi-electron density.

  DOI：

  10.1023/a:1023376826251
• 作为产物：
  描述：

  methyl 2-(diethoxyphosphoryl)imino-3,3,3-trifluoropropionate 在 水 作用下， 生成 methyl 2-hydroxy-2-diethoxyphosphorylamino-3,3,3-trifluoropropionate
  参考文献：
  名称：

  摘要：

  The first example of trifluoropyruvate phosphorylimines was prepared, and its capability for O- and S-amidoalkylation of water, alcohols, and compounds with the SH function was shown. Phenol and 4-methoxyphenol are O-alkylated, while 3-dimethylaminophenol and indole undergo regiospecific C-alkylation at the site of the highest pi-electron density.

  DOI：

  10.1023/a:1023376826251

文献信息

• ——
  作者：P. P. Onys'ko

  DOI：10.1023/a:1023376826251

  日期：——

  The first example of trifluoropyruvate phosphorylimines was prepared, and its capability for O- and S-amidoalkylation of water, alcohols, and compounds with the SH function was shown. Phenol and 4-methoxyphenol are O-alkylated, while 3-dimethylaminophenol and indole undergo regiospecific C-alkylation at the site of the highest pi-electron density.