苄基-苯丙氨酰-甲酯.盐酸盐 | 7703-09-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 苄基-苯丙氨酰-甲酯.盐酸盐
• 中文别名: N-(苯基甲基)-L-苯丙氨酸甲酯盐酸盐
• 英文名称: N-benzylphenylalanine methyl ester hydrochloride
• 英文别名: benzyl-[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]azanium;chloride
• CAS: 7703-09-5
• 化学式: C₁₇H₂₀NO₂*Cl
• mdl: MFCD02684383
• 分子量: 305.804
• InChiKey: FKTZZMDPUTVSOH-NTISSMGPSA-N

物化性质

• 熔点：
  145 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.38
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.235
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  苄基-苯丙氨酰-甲酯.盐酸盐 在 盐酸 作用下， 反应 24.0h， 以100%的产率得到N-benzylphenylalanine hydrochloride
  参考文献：
  名称：

  Metabolism of phencyclidine. The role of the carbinolamine intermediate in the formation of lactam and amino acid metabolites of nitrogen heterocycles

  摘要：

  The transformation of phencyclidine in a mouse liver microsome preparation to several oxidative metabolites was studied. With use of GLC and HPLC methods with internal standards, phencyclidine and six metabolites were quantitated and the amino acid 12, resulting from the alpha-oxidation of the piperidine ring, was produced in 10-50 times greater amounts than the other metabolites. While most piperidines and pyrrolidines produce an amino acid and a corresponding lactam, it was found that phencyclidine was not converted to the lactam 11.

  DOI：

  10.1021/jm00379a011

文献信息

• Catalytic Staudinger/Aza-Wittig Sequence by in situ Phosphane Oxide Reduction
  作者：Henri A. van Kalkeren、Colet te Grotenhuis、Frank S. Haasjes、C. Rianne A. Hommersom、Floris P. J. T. Rutjes、Floris L. van Delft

  DOI：10.1002/ejoc.201300585

  日期：2013.11

  A Staudinger/aza-Wittig reaction sequence is described that is catalytic in phosphorus. Towards this end, the phosphane oxide is reduced in situ by diphenylsilane, which allows for substoichiometric amounts of the catalyst 5-phenyldibenzophosphole to be used. The substrate scope is investigated and benzoxazoles, benzodiazepine imidates and a 2-methoxypyrrole were successfully synthesized. These investigations

  描述了在磷中具有催化作用的 Staudinger/aza-Wittig 反应序列。为此，氧化膦被二苯基硅烷原位还原，这允许使用亚化学计量量的催化剂5-苯基二苯并磷。研究了底物范围并成功合成了苯并恶唑、苯并二氮杂亚胺酯和2-甲氧基吡咯。这些研究表明，需要快速的 aza-Wittig 反应才能获得高产率。
• Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof
  申请人：Evans Karen

  公开号：US20070249670A1

  公开（公告）日：2007-10-25

  The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.

  本发明涉及糖原磷酸化酶抑制剂化合物、这些化合物的药物组合物、使用这些药物组合物治疗糖尿病、与糖尿病相关的疾病和/或组织缺血，包括心肌缺血的方法，以及制备这些化合物的过程。
• Pyrrole Compounds Having Sphingosine-1-Phosphate Receptor Agonist Or Antagonist Biological Activity
  申请人：Beard Richard L.

  公开号：US20110105567A1

  公开（公告）日：2011-05-05

  Disclosed herein are compounds represented by: therapeutic methods, compositions, and medicaments related thereto are also disclosed.

  本文披露了以下化合物：与之相关的治疗方法、组成物和药物也被披露。
• Methods for modulating taste receptors
  申请人：MARS, INCORPORATED

  公开号：US11185100B2

  公开（公告）日：2021-11-30

  Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

  本文描述了存在于鲜味受体结构域中的氨基酸，其中氨基酸与至少一种核苷酸衍生物和/或至少一种跨膜化合物相互作用，从而增强、调节、增加和/或提高鲜味受体的活性。此类化合物可用于调味组合物，以增强食品的鲜味和/或适口性。
• Trampisch, Herbert; Beck, Wolfgang, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983, vol. 38, # 3, p. 365 - 369
  作者：Trampisch, Herbert、Beck, Wolfgang

  DOI：——

  日期：——