5-Bromo-2-(1-ethoxyethoxy)benzaldehyde | 1033090-22-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-Bromo-2-(1-ethoxyethoxy)benzaldehyde
• CAS: 1033090-22-0
• 化学式: C₁₁H₁₃BrO₃
• 分子量: 273.126
• InChiKey: HUDGDUTUHXFOKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-Bromo-2-(1-ethoxyethoxy)benzaldehyde 、 氰乙酸乙酯 在 3 A molecular sieve 作用下， 以 乙醇 为溶剂， 以65%的产率得到ethyl (E)-3-[5-bromo-2-(1-ethoxyethoxy)phenyl]-2-cyanoprop-2-enoate
  参考文献：
  名称：

  The synthesis of new, selected analogues of the pro-apoptotic and anticancer molecule HA 14-1

  摘要：

  A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde, allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2'. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.070
• 作为产物：
  描述：

  乙烯基乙醚 、 5-溴水杨醛 在 camphor-10-sulfonic acid 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以90%的产率得到5-Bromo-2-(1-ethoxyethoxy)benzaldehyde
  参考文献：
  名称：

  The synthesis of new, selected analogues of the pro-apoptotic and anticancer molecule HA 14-1

  摘要：

  A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde, allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2'. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.070

文献信息

• The synthesis of new, selected analogues of the pro-apoptotic and anticancer molecule HA 14-1
  作者：Danielle Grée、Samuel Vorin、Vijay L. Manthati、Frédéric Caijo、Guillaume Viault、Florence Manero、Philippe Juin、René Grée

  DOI：10.1016/j.tetlet.2008.03.070

  日期：2008.5

  A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde, allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2'. (c) 2008 Elsevier Ltd. All rights reserved.